Protective effect of Oxalis corniculate and pteropyrum scoparium Leaf extracts against Azoxymethane-induced oxidative stress and colon carcinogenesis
العناوين الأخرى
التأثير الوقائي لمستخلص أوراق النباتات البرية العمانية (السيداف و الحميضة) ضد الإجهاد التأكسدي الناجم عن تسرطن القولون في حيوانات التجارب
المؤلفون المشاركون
Wali, Mustafa I.
Guizani, Najib
al-Khusaibi, Muhammad
المصدر
Agricultural and Marine Sciences : Research Journal
العدد
المجلد 26، العدد 1 (30 يونيو/حزيران 2021)، ص ص. 47-52، 6ص.
الناشر
جامعة السلطان قابوس كلية العلوم الزراعية والبحرية
تاريخ النشر
2021-06-30
دولة النشر
سلطنة عمان
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
-Oxalis corniculate and Pteropyrum scoparium are two edible wild Omani plants with known preventive effects on various human diseases, yet their therapeutic role in colon cancer has not been studied yet.
Azoxymethane (AOM) is a common oxidizing agent that induces colon cancer in experimental animal models.
In the current study, the protective effect of Oxalis corniculate and Pteropyrum scoparium leaves extracts against AOM-induced cancer and oxidative stress in rat colon was examined.
Sixty Sprague-Dawley rats were randomly divided into 6 groups (10 rats/group).
Control group was fed a standard diet; the AOM-treated group was fed a standard diet and received an intraperitoneal injection of AOM at a dose of 30 mg/kg body weight for each rat.
The other four groups received an intra-gastric intubation of Pteropyrum scoparium or Oxalis corniculate leaves extracts (0.1 mg extract/1 mL water/day) in the absence or presence of AOM injection.
After 8 weeks, all rats were sacrificed and the colon tissues were dissected for Aberrant Crypt Foci (ACF) enumeration of cancer lesions development, and for measurements of glutathione (GSH), total antioxidant capacity (TAC), and DNA oxidative damage.
The results in this study showed that the AOM-injected rats showed significant increased level of DNA oxidative damage, lower levels of GSH and TAC, and higher ACF as compared to the control group.
Oxalis corniculate and Pteropyrum scoparium leaf extracts significantly suppressed the oxidative damage associated with AOM injection and mitigated its carcinogenic effect in rat colon.
Both Oxalis corniculate and Pteropyrum scoparium leaf extracts acted as potent antioxidants and combat the AOM-associated oxidative stress and colon carcinogenesis.
The data from this study suggest that dietary supplementation of these two wild plants might be applied as a therapeutic agent for colon cancer treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wali, Mustafa I.& Guizani, Najib& al-Khusaibi, Muhammad. 2021. Protective effect of Oxalis corniculate and pteropyrum scoparium Leaf extracts against Azoxymethane-induced oxidative stress and colon carcinogenesis. Agricultural and Marine Sciences : Research Journal،Vol. 26, no. 1, pp.47-52.
https://search.emarefa.net/detail/BIM-1341538
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wali, Mustafa I.…[et al.]. Protective effect of Oxalis corniculate and pteropyrum scoparium Leaf extracts against Azoxymethane-induced oxidative stress and colon carcinogenesis. Agricultural and Marine Sciences : Research Journal Vol. 26, no. 1 (2021), pp.47-52.
https://search.emarefa.net/detail/BIM-1341538
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wali, Mustafa I.& Guizani, Najib& al-Khusaibi, Muhammad. Protective effect of Oxalis corniculate and pteropyrum scoparium Leaf extracts against Azoxymethane-induced oxidative stress and colon carcinogenesis. Agricultural and Marine Sciences : Research Journal. 2021. Vol. 26, no. 1, pp.47-52.
https://search.emarefa.net/detail/BIM-1341538
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 52
رقم السجل
BIM-1341538
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر