مراقبة الأدوية العلاجية : الأساسيات و التحسين : مراجعة الخبراء

الملخص EN

Therapeutic drug monitoring (TDM) is a teamwork clinical pharmacokinetic service that aims to optimize the pharmacotherapy of certain drugs such as those with a narrow therapeutic range, complicated pharmacokinetics.

It involves the determination of drug levels in blood samples taken at the appropriate time.

Interpretation of results requires the integration of pharmacokinetics, the pharmacodynamics of the drug, and the patient’s clinical profile.

To be cost-effective, the service should be optimized.

This review highlights the fundamentals of TDM service and provides practical suggestions for its optimization specially in developing countries.

It covers the rationale of requesting drug level, design of request form, optimal sampling, and analytical tools.

It provides guidelines for appropriate interpretation of drug levels, completeness of the roles of the qualified medical team, continuing education and skills development, involving the patients in improving the service, conducting relevant research, and the use of PK software and integration of TDM with pharmacogenomics.