Interpreting a diagnosis of atypical squamous cells of undetermined significance in cervical cytology and its association with human papillomavirus : a retrospective analysis of 180 cases in Kuwait
العناوين الأخرى
تفسير تشخيص الخلايا الحرشفية اللاتمطية غير محددة الدلالة في شريحة خلايا عنق الرحم و ارتباطها بفيروس الورم الحليمي البشري : تحليل استعادي ل 180 حالة في الكويت
المؤلفون المشاركون
Balakrishna, Meera
Ali, Rula Husayn
al-Juwaysir, Ahlam
Mallik, Mrinmay K.
Kapila, Kusum
George, Sara S.
المصدر
Sultan Qaboos University Medical Journal
العدد
المجلد 20، العدد 4 (30 نوفمبر/تشرين الثاني 2020)، ص ص. 318-323، 6ص.
الناشر
جامعة السلطان قابوس كلية الطب و العلوم الصحية
تاريخ النشر
2020-11-30
دولة النشر
سلطنة عمان
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objectives: Atypical squamous cells of undetermined significance (ASC-US) represent a diagnostic challenge during cervical cytology.
This study aimed to review and identify high-risk human papillomavirus (HR-HPV) genotypes among previously diagnosed ASC-US cases in Kuwait.
Methods: This retrospective study analysed 180 cases diagnosed as ASC-US between June 2017 and May 2018 at the Mubarak Al-Kabeer Hospital, Kuwait.
Cervical specimens were assayed to determine the presence of HR-HPV DNA; subsequently, positive cases underwent genotyping and were categorised into three groups (HPV 16, HPV 18/45 and other HR-HPV types).
Results: In total, ASC-US was confirmed in only 105 cases (58.3%), with the remaining cases reclassified as negative for intraepithelial lesions or malignancy (NILM; 32.2%) and epithelial cell abnormalities (ECA; 9.4%).
Of these, HRHPV DNA was present in 20 ASC-US (19%), one NILM (1.7%) and six ECA (35.3%) cases.
There were 62 Kuwaiti and 43 non-Kuwaiti women with confirmed ASC-US; of these, three (4.8%), six (9.7%) and four (6.5%) Kuwaitis and one (2.3%), one (2.3%) and five (11.6%) non-Kuwaitis had HPV 16, both HPV 16 and 18/45 and other HRHPV genotypes, respectively.
Of those with HR-HPV DNA, the NILM case had the HPV 18/45 genotype, while the six ECA cases had the HPV 16 (n = 1), both HPV 16 and 18/45 (n = 1) and other HR-HPV (n = 4) genotypes.
Conclusion: Overall, HR-HPV DNA was present in 19% of ASC-US cases compared to 1.7% of NILM cases initially misdiagnosed as ASC-US.
Re-review of cervical cytology diagnoses may reduce unnecessary costs associated with HR-HPV genotyping.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kapila, Kusum& Balakrishna, Meera& Ali, Rula Husayn& al-Juwaysir, Ahlam& George, Sara S.& Mallik, Mrinmay K.. 2020. Interpreting a diagnosis of atypical squamous cells of undetermined significance in cervical cytology and its association with human papillomavirus : a retrospective analysis of 180 cases in Kuwait. Sultan Qaboos University Medical Journal،Vol. 20, no. 4, pp.318-323.
https://search.emarefa.net/detail/BIM-1342905
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kapila, Kusum…[et al.]. Interpreting a diagnosis of atypical squamous cells of undetermined significance in cervical cytology and its association with human papillomavirus : a retrospective analysis of 180 cases in Kuwait. Sultan Qaboos University Medical Journal Vol. 20, no. 4 (Nov. 2020), pp.318-323.
https://search.emarefa.net/detail/BIM-1342905
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kapila, Kusum& Balakrishna, Meera& Ali, Rula Husayn& al-Juwaysir, Ahlam& George, Sara S.& Mallik, Mrinmay K.. Interpreting a diagnosis of atypical squamous cells of undetermined significance in cervical cytology and its association with human papillomavirus : a retrospective analysis of 180 cases in Kuwait. Sultan Qaboos University Medical Journal. 2020. Vol. 20, no. 4, pp.318-323.
https://search.emarefa.net/detail/BIM-1342905
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 322-323
رقم السجل
BIM-1342905
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر