A study of alt elevation in association with triglycerides, cholesterol and glucose elevation in human serum

الملخص EN

Objective : Non Alcoholic Fatty Liver Disease (NAFLD)is very common.

Obesity, insulin resistant diabetes, cholesterol components disturbance and elevation of triglyceride are considered the most important causes of this disease.

At an early stage of the disease, one of the major elevated enzymes is the (ALT) (Alanin Amino transferase) enzyme.

Accordingly, it is justified to assume that an elevation of one of the blood figures glucose, cholesterol and triglyceride or their combination, will have a major effect on increasing the number of cases of elevated (ALT) in blood.

This study, aimed at defining.

An existence of an association between:1- The high levels glucose group versus normal glucose group.

2-(The high levels cholesterol group versus normal cholesterol group).

3- The high levels triglyceride group versus normal triglyceride group).

4-The group having high Triglyceride versus the group having combined high triglyceride and high glucose and the group having triglyceride, glucose and cholesterol elevated.

5- The group having high Triglyceride versus the group having combined high cholesterol and high glucose).

And the increase in the number of cases of elevated serum ALT in blood. Methods: The sample consisted of 245 of both males and females who had their serum ALT detected after defining the obesity in the study group as the: (waist circumference ? 85 cm).

In each study case the sample was divided into two groups normal and abnormal.

A study was conducted on the effect of the elevated level of each of the three parameters (Glucose, Cholesterol and Triglyceride) on ALT elevation.

Chi-Square test was used as a mean of comparing the results. Results: When compared to normal levels, high glucose or high cholesterol showed no significant difference in increase cases of high ALT in blood > 45 iu / ml.

When triglyceride was elevated in blood > 150-mg/ dl, it was associated with an increase in the number of cases of high ALT in blood.

The combination of high glucose and cholesterol or high glucose, cholesterol and triglyceride when compared to high triglyceride alone did not show any significant difference in elevated cases of high ALT in blood.

The combination effect of both high cholesterol and high glucose is equivalent to the high triglyceride effect on the increase in the number of cases of high ALT in blood. Conclusions: High triglyceride, regardless of its association with the elevation in glucose or cholesterol or both, has a role to play in fatty liver disease development and progress.

The elevation of triglyceride in blood can cause harm to the hepatocytes due to its association with the enzyme ALT elevation.

High glucose or high cholesterol alone on the other hand, did not show any significant effect on ALT elevation.

The equivalent effect of the combination of both high glucose and high cholesterol to the effect of high triglyceride on ALT elevation is justified not only by their direct effect on elevating ALT but indirectly on elevating triglyceride which by itself causes the elevation in ALT.