The lapin immune states associated with intramuscular injection of heat killed helicobacter pylori

الملخص EN

Nowadays, helicobacter pylori is considered to be the most common human bacteria in the pathogenesis of chronic gastritis and peptic ulcer diseases.

the immunogen administered to an animal may have a profound on the outer come of the immune responses.

four successive doses of heat killed H.pylori (HpHK) bacteria was intramuscular injected in rabbits at five days a part manner.

HpHK bacteria stimulate specific mucosal and systemic humoral and cellular immune responses determined by raised in the immunoglobulin titers and concentrations, increased the concentrations of C3 and C4 which are the complement compartments with significant increase in the lymphoid cells that formed the rosette form , significant migration inhibition index , increased the concentrations of cytokines (IL-4 & IL-8) .

HpHk induced positive skin test tuberculin type delayed hypersensitivity, in addition to the histopathological changes at different body organ portions of the animals.