Immunological and biochemical studies on polyvalent pasteurella vaccine in camels

الملخص EN

-Camel pasteurellosis is a bacterial disease affecting respiratory system of camels caused by Pasteurella species.

In Egypt, there are no recommended vaccination programs of camel against pasteurellosis.

Therefore, evaluation of the efficacy of a polyvalent Pasteurella vaccine in camels is the main target of this research focusing the attention on its immunological and biochemical patterns of response.

The humeral immune responses in two different camel groups (vaccinated and control) were evaluated by indirect haemagglutination test (IHA) and Passive Mouse Protection Test.

The biochemical profiles of different camel groups were estimated.

In addition to, the assessment of lipid peroxidation and Matrix Metalloproteinase enzymes (MMP2 & MMP9) activity of camels under this vaccination trial.

Significant positive humeral responses against different vaccinal Pasteurella species were recorded in the vaccinated camel group and reached their peaks (1:64-1:256) around the 3th month post vaccination.

An evident passive mouse protection against the challenge of virulent strains of P.

multocida type A, B and D and Mannheimia haemolytica types A & T were also recorded.

Biochemically, there were no significant differences in the biochemical profiles, lipid peroxidation and Matrix Metalloproteinase (MMP) enzymes activity between the vaccinated and control group.

It's recommended to include camels in the epidemiological studies and periodical vaccination programs (every 6th months) in parallel with other contact animal species to perform a high protection and good control managements of pasteurellosis in Egypt.