Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study
المؤلفون المشاركون
Wadaha, Husayn Abd al-Zahrah
Khamis, Muhammad Hasib
Meshay, Hasan Didi
المصدر
العدد
المجلد 19، العدد 2 (30 يونيو/حزيران 2022)، ص ص. 157-161، 5ص.
الناشر
تاريخ النشر
2022-06-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : the pathogenesis β-thalassemia is characterized by anemia resulting from reduced β-globin synthesis with low hemoglobin a (HbA) production and higher production of hemoglobin A2 (HbA2) and fetal hemoglobin (HbF).
however, thromboembolic events have been recently identified in patients with β-thalassemia due to hypercoagulable state.
Objectives : the aim of this study was to evaluate the levels of some coagulation markers in Iraqi patients with β-thalassemia major and β-thalassemia intermedia.
materials and methods : the study included three groups.
the first group included patients with β-thalassemia major (n = 39), the second group included patients with β-thalassemia intermedia (n = 11), and third group included 20 apparently healthy control subjects.
each of prothrombin time (PT), activated partial thromboplastin time (APTT), antithrombin III (ATIII), and thrombin-antithrombin III (TAT) complex were measured according to the standard protocols.
results : both PT and APTT in β-thalassemia major and β-thalassemia intermedia were higher than that of the control group with a highly significant difference (P = 0.002), whereas no significant differences were observed between patients with β-thalassemia major and β-thalassemia intermedia.
mean ATIII level was highest in the control group followed by β-thalassemia intermedia and then by β-thalassemia major groups (P < 0.001), whereas mean TAT complex was highest in thalassemia major group followed by β-thalassemia intermedia and then by control groups (P < 0.001).
conclusions : prolonged PT and APTT in patients with β-thalassemia together with the reduction in the level of anticoagulant factor (ATII) suggest a role for liver impairment ; however, the significantly higher TAT complex is suggestive of ongoing activation of coagulation cascade in patients with β-thalassemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wadaha, Husayn Abd al-Zahrah& Meshay, Hasan Didi& Khamis, Muhammad Hasib. 2022. Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study. Medical Journal of Babylon،Vol. 19, no. 2, pp.157-161.
https://search.emarefa.net/detail/BIM-1382304
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wadaha, Husayn Abd al-Zahrah…[et al.]. Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study. Medical Journal of Babylon Vol. 19, no. 2 (Apr. / Jun. 2022), pp.157-161.
https://search.emarefa.net/detail/BIM-1382304
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wadaha, Husayn Abd al-Zahrah& Meshay, Hasan Didi& Khamis, Muhammad Hasib. Changes in coagulation status in patients with β-thalassemia in Iraq : a case-control study. Medical Journal of Babylon. 2022. Vol. 19, no. 2, pp.157-161.
https://search.emarefa.net/detail/BIM-1382304
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 161
رقم السجل
BIM-1382304
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر