Molecular study of IL-7R gene polymorphism and their associations with male multiple sclerosis patients in Erbil province
المؤلفون المشاركون
Karim, Abd al-Karim Y.
Smail, Shukur W.
Ali, Mukhlis H.
Pirdawid, Ahmad O.
Sharif, Abd Allah A.
Yasin, Ruza T.
Mustafa, Muhammad Q.
Jalal, Kovan F.
Qadir, Fikri A.
Salih, Abbas
المصدر
ZANCO Journal of Pure and Applied Sciences
العدد
المجلد 33، العدد 1 (28 فبراير/شباط 2021)، ص ص. 21-26، 6ص.
الناشر
جامعة صلاح الدين قسم النشر العلمي
تاريخ النشر
2021-02-28
دولة النشر
العراق
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Multiple sclerosis (MS) is an autoimmune disease in which immune cells attacks the body cells mistakenly; it is characterized by chronic inflammation that leads to demyelination and conduction of nerve impulse is affected negatively.
The cause of the disease is unknown, but it may be partially under the control of genetics, including interleukin 7 receptor alpha (IL7Rα).
In this case-control study, 40 relapsing-remitting MS (RRMS) male patients, which fulfills McDonald criteria and 40 healthy controls, with matched sex, were compared depending on the rs6897932 polymorphism within the exon 6 of IL7Rα gene by Tetra-amplification refractory mutation system polymerase chain reaction (Tetra-ARMS-PCR) method.
The frequency of T allele of IL7Rα rs6897932 was considerably higher in male MS patients than healthy control males (31.25 vs 17.5%).
Genotype distributions of the single nucleotide polymorphism (SNP) rs6897932 deviated from Hardy-Weinberg equilibrium with a p-value of 0.80.
Both homozygous (TT) and Heterozygous (CT) were non-significantly positively associated with MS male patients (OR = 6.75, 95%CI = 0.73-62.4, p = 0.059, OR = 1.68, 95%CI = 0.64-4.38, p = 0.28) respectively.
The distribution of the rs6897932 polymorphism is not significantly different in our case/control study in the Erbil province
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smail, Shukur W.& Ali, Mukhlis H.& Qadir, Fikri A.& Pirdawid, Ahmad O.& Sharif, Abd Allah A.& Karim, Abd al-Karim Y.…[et al.]. 2021. Molecular study of IL-7R gene polymorphism and their associations with male multiple sclerosis patients in Erbil province. ZANCO Journal of Pure and Applied Sciences،Vol. 33, no. 1, pp.21-26.
https://search.emarefa.net/detail/BIM-1387342
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smail, Shukur W.…[et al.]. Molecular study of IL-7R gene polymorphism and their associations with male multiple sclerosis patients in Erbil province. ZANCO Journal of Pure and Applied Sciences Vol. 33, no. 1 (2021), pp.21-26.
https://search.emarefa.net/detail/BIM-1387342
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smail, Shukur W.& Ali, Mukhlis H.& Qadir, Fikri A.& Pirdawid, Ahmad O.& Sharif, Abd Allah A.& Karim, Abd al-Karim Y.…[et al.]. Molecular study of IL-7R gene polymorphism and their associations with male multiple sclerosis patients in Erbil province. ZANCO Journal of Pure and Applied Sciences. 2021. Vol. 33, no. 1, pp.21-26.
https://search.emarefa.net/detail/BIM-1387342
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 25-26
رقم السجل
BIM-1387342
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر