Synthesis, computational study, and antibacterial activity of rhodanine and thiazolidine-2,4-dione scaffolds
المؤلفون المشاركون
Amin, Rozh Qasim
Ahmad, Hiwa Umar
المصدر
ZANCO Journal of Pure and Applied Sciences
العدد
المجلد 32، العدد 3 (30 يونيو/حزيران 2020)، ص ص. 139-156، 18ص.
الناشر
جامعة صلاح الدين قسم النشر العلمي
تاريخ النشر
2020-06-30
دولة النشر
العراق
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
In this research, different thiazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives (1-13) have been synthesized by knoevenagel condensation (1-13).
thiazolidine-2,4-dione and 2-thioxothiazolidin-4-one derivatives have an important role in medicinal chemistry and drug design.
all synthesized compounds (1-13) have been confirmed by ir, ¹h and ¹³c-nmr spectral data.
a computational study was used to determine values of the lowest unoccupied molecular orbital and highest occupied molecular orbital energy gap to show the chemical stability, and reactivity of compounds (1-13).
small values of energy between a lowest unoccupied molecular orbital and a highest occupied molecular orbital energy gap indicate chemical stability and reactivity of synthesized compounds.
elumo-homo ranged between 0.004-0.306 ev indicated high reactivity of the prepared molecule.
thermodynamic energies have been calculated for synthesized compounds including enthalpy, entropy, and Gibbs free energy, negative values have been detected for all synthesized compounds (1-13).
antibacterial activity has done for all synthesized compounds (1-13) against gram-positive staphylococcus aureus and gram-negative Escherichia coli by the method of disc diffusion show that all synthesized compounds except 7, 8, 11 and 13 have antibacterial effect for both or one type of bacteria.
antibacterial activity is observed as a clear circular zone of inhibition for selected synthesized compounds by disc inhibition zones of staphylococcus aureus, and Escherichia coli bacteria.
the range for staphylococcus aureus were between (6-24 )mm and for Escherichia coli were between (6-18)mm, the measuring of the zones were with the discs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Amin, Rozh Qasim& Ahmad, Hiwa Umar. 2020. Synthesis, computational study, and antibacterial activity of rhodanine and thiazolidine-2,4-dione scaffolds. ZANCO Journal of Pure and Applied Sciences،Vol. 32, no. 3, pp.139-156.
https://search.emarefa.net/detail/BIM-1402417
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Amin, Rozh Qasim& Ahmad, Hiwa Umar. Synthesis, computational study, and antibacterial activity of rhodanine and thiazolidine-2,4-dione scaffolds. ZANCO Journal of Pure and Applied Sciences Vol. 32, no. 3 (2020), pp.139-156.
https://search.emarefa.net/detail/BIM-1402417
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Amin, Rozh Qasim& Ahmad, Hiwa Umar. Synthesis, computational study, and antibacterial activity of rhodanine and thiazolidine-2,4-dione scaffolds. ZANCO Journal of Pure and Applied Sciences. 2020. Vol. 32, no. 3, pp.139-156.
https://search.emarefa.net/detail/BIM-1402417
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 153-156.
رقم السجل
BIM-1402417
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر