Dexmedetomidine protects against degeneration of dopaminergic neurons and improves motor activity in Parkinson’s disease mice model
المؤلفون المشاركون
Zhao, Xin
Wang, Fang
Wu, Li
Zhang, Bao-ping
Wu, Xian-wei
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 6 (30 يونيو/حزيران 2021)، ص ص. 3198-3203، 6ص.
الناشر
تاريخ النشر
2021-06-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Parkinson’s disease (PD) is the result of dopaminergic (DA) neuronal death in the substantianigra pars compacta (SNc).
Current treatments for PD such as L-dopa are limited in effectiveness and fail to address the cause.
Targeted anti-inflammatory therapies, particularly directed at nuclear factor kappa B (NF-jB) activity in alleviating degeneration of DA-neurons is of evolving interest.
In the present study, we hypothesised that dexmedetomidine (DEX), an alpha-2 receptor adrenergic agonist, suppress the inflammatory responses associated with PD and restores dopaminergic levels by alleviating substantia nigral degeneration.
Male mice (C57Bl/10, 8–11 months old and of 34–40 g of weight) were divided into: the control, 1- methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and MPTP + dexmedetomidine (MPTP + DEX) (n = 26 each group).
Dex restored dopamine levels in SNpc of MPTP-induced PD mice model.
Results of immunohisto staining revealed that Dex treatment post-MPTP induction restored TH-positive cells, with only 12.37% increase (##p < 0.01 vs MPTP) on the third day and a steep 55% increase(###p < 0.001 vs MPTP) following the seventh day of Dex treatment.
Moreover, the expressions of proinflammatory markers regulated by NF-jB were diminished in Dex + MPTP group.
In addition, cylinder test revealed that Dex treatment improved asymmetric limb usage pattern in MPTP induced mice over the course of 7 days.
Hence, in this study, we provided insight on the effect of Dex in the inhibition of NFjB1 regulated proinflammatory mediators to improve dopamine levels and reduce SNpc dopaminergic neuronal degeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Bao-ping& Wu, Li& Wu, Xian-wei& Wang, Fang& Zhao, Xin. 2021. Dexmedetomidine protects against degeneration of dopaminergic neurons and improves motor activity in Parkinson’s disease mice model. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3198-3203.
https://search.emarefa.net/detail/BIM-1407770
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Bao-ping…[et al.]. Dexmedetomidine protects against degeneration of dopaminergic neurons and improves motor activity in Parkinson’s disease mice model. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3198-3203.
https://search.emarefa.net/detail/BIM-1407770
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Bao-ping& Wu, Li& Wu, Xian-wei& Wang, Fang& Zhao, Xin. Dexmedetomidine protects against degeneration of dopaminergic neurons and improves motor activity in Parkinson’s disease mice model. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3198-3203.
https://search.emarefa.net/detail/BIM-1407770
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3203
رقم السجل
BIM-1407770
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر