RUNX1 mutation and elevated FLT3 gene expression cooperates to induce inferior prognosis in cytogenetically normal acute myeloid leukemia patients
المؤلفون المشاركون
Hamid, Nailah
Qamar, Saminah
Chaudhary, Asma
Sayyid, Sami
Rahman, Atiyyah
Akram, Afiyah Muhammad
Shaykh, Nadim
Husayn, Zawar
al-Sani, Wala Fahd Muhammad
Abd al-Rahman, Rahat
Salim, Tayyibah
Zafar, Amjad
Absar, Muhammad
Baashin, Husam Ali
Muhammad Salih, Zuhayr Muhammad
al-Hazimi, Ala
Jabir, Ahmad
Iqbal, Zafar
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 9 (30 سبتمبر/أيلول 2021)، ص ص. 4845-4851، 7ص.
الناشر
تاريخ النشر
2021-09-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Acute myeloid leukemia (AML) is a bone marrow malignancy having multiple molecular pathways driving its progress.
In recent years, the main causes of AML considered all over the world are genetic variations in cancerous cells.
The RUNX1 and FLT3 genes are necessary for the normal hema-topoiesis and differentiation process of hematopoietic stem cells into mature blood cells, therefore they are the most common targets for point mutations resulting in AML.
Methods: We screened 32 CN-AML patients for FLT3-ITD (by Allele-specific PCR) and RUNX1 mutations (by Sanger sequencing).
The FLT3 mRNA expression was assessed in all AML patients and its subgroups.
Results: Eight patients (25%) carried RUNX1 mutation (K83E) while three patients (9.37%) were found to have internal tandem duplications in FLT3 gene.
The RUNX1 mutation data were correlated with clinical parameters and FLT3 gene expression profile.
The RUNX1 mutations were observed to be significantly prevalent in older males.
Moreover, RUNX1 and FLT3-mutated patients had lower complete remission rate, event-free survival rate, and lower overall survival rate than patients with wild-type RUNX1 and FLT3 gene.
The RUNX1 and FLT3 mutant patients with up-regulated FLT3 gene expression showed even worse prognosis.
Bradford Assay showed that protein concentration was down-regulated in RUNX1 and FLT3 mutants in comparison to RUNX1 and FLT3 wild-type groups.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rahman, Atiyyah& Akram, Afiyah Muhammad& Chaudhary, Asma& Shaykh, Nadim& Husayn, Zawar& al-Sani, Wala Fahd Muhammad…[et al.]. 2021. RUNX1 mutation and elevated FLT3 gene expression cooperates to induce inferior prognosis in cytogenetically normal acute myeloid leukemia patients. Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.4845-4851.
https://search.emarefa.net/detail/BIM-1410061
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rahman, Atiyyah…[et al.]. RUNX1 mutation and elevated FLT3 gene expression cooperates to induce inferior prognosis in cytogenetically normal acute myeloid leukemia patients. Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.4845-4851.
https://search.emarefa.net/detail/BIM-1410061
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rahman, Atiyyah& Akram, Afiyah Muhammad& Chaudhary, Asma& Shaykh, Nadim& Husayn, Zawar& al-Sani, Wala Fahd Muhammad…[et al.]. RUNX1 mutation and elevated FLT3 gene expression cooperates to induce inferior prognosis in cytogenetically normal acute myeloid leukemia patients. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.4845-4851.
https://search.emarefa.net/detail/BIM-1410061
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4851
رقم السجل
BIM-1410061
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر