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Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K-AKT-mTOR signaling pathway
المؤلفون المشاركون
Zhang, Shouqiang
Sun, Hanting
Cao, Songhua
Ren, Hui
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 9 (30 سبتمبر/أيلول 2021)، ص ص. 4908-4915، 8ص.
الناشر
تاريخ النشر
2021-09-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Osteosarcoma (OS) is the most common malignant bone cancer with more metastasis and increased occurrence in children and teen-agers and being responsible for more number of morbidity and mortality worldwide.
Objective: The current exploration was planned study the in vitro anticancer actions of dieckol against human OS MG-63 cells via PI3K/AKT/mTOR signaling inhibition.
Methodology: The cytotoxicity of dieckol was scrutinized by MTT assay.
Effects of dieckol on the ROS accumulation, apoptotic cell death, and MMP level in the MG-63 cells were studied by respective fluorescence staining assays.
The levels of proliferative, inflammatory, and apoptotic markers in the dieckol treated MG-63 cells were scrutinized by marker specific kits.
The expressions of PI3K, AKT, and mTOR was assayed by RT-PCR.
Results: The MTT assay revealed that the dieckol dose dependently prevented MG-63 cells viability and the IC50 was found at 15 µM.
Dieckol treatment effectively reduced the MMP level and improved the ROS generation and apoptosis in MG-63 cells.
Dieckol also regulated the proliferative (cyclin D1), inflammatory (COX-2, IL-6, TNF-α, and NF-κB), and apoptotic (caspase-3, Bax, Bcl-2) markers in the MG-63 cells.
The PI3K/AKT/mTOR signaling in the MG-63 cells were effectively inhibited by the dieckol treatment.
Conclusion: In conclusion, our findings from this study recommends that the dieckol could be a talented anticancer candidate for the OS management in the future
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Shouqiang& Ren, Hui& Sun, Hanting& Cao, Songhua. 2021. Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K-AKT-mTOR signaling pathway. Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.4908-4915.
https://search.emarefa.net/detail/BIM-1410082
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Shouqiang…[et al.]. Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K-AKT-mTOR signaling pathway. Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.4908-4915.
https://search.emarefa.net/detail/BIM-1410082
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Shouqiang& Ren, Hui& Sun, Hanting& Cao, Songhua. Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K-AKT-mTOR signaling pathway. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.4908-4915.
https://search.emarefa.net/detail/BIM-1410082
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 4914-4915
رقم السجل
BIM-1410082
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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