A new cerebral ischemic injury model in rats, preventive effect of gallic acid and in silico approaches
المؤلفون المشاركون
Praveen Kumar, P.
Madhuri, D.
Siva Sankar Reddy, L.
Somasekhar, G.
Sirisha, N. V. L.
Nagaraju, K.
Shouib, M. S. A.
Rizwaan, S.
Dastagiri Reddy, Y.
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 9 (30 سبتمبر/أيلول 2021)، ص ص. 5204-5213، 10ص.
الناشر
تاريخ النشر
2021-09-30
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Current study was designed multiple occlusions and reperfusion of bilateral carotid arteries induced cerebral injury model and evaluated the protective effect of gallic acid on it.
In silico study was involved to study gallic acid binding affinity on cerebrotonic proteins compared with standard drugs using Autodoc vina tool.
Cerebral ischemia was induced by occlusion of bilateral common carotid arteries for 10 mins followed by 10 reperfusions (1 cycle), cycle was continued to 3 cycles (MO/RCA), then pathological changes were observed by estimation of brain antioxidants as superoxide dismutase, glutathione, catalase, oxidants like malonaldehyde, cerebral infarction area, histopathology, and study gallic acid treatment against cerebral injury.
Gallic acid exhibited a strong binding affinity on targeted cerebrotoxic proteins.
MO/RCA rat brain antioxidant levels were significantly decreased and increased MDA levels (p < 0.0001), Infarction size compared to sham rats.
Gallic acid treatment rat brain MDA levels significantly decreased (p < 0.4476) and increased SOD (p < 0.0001), CAT (p < 0.0001), GSH (p < 0.0001), cerebral infarction area when compared to MO/RCA group.
Developed model showed significant cerebral ischemic injury in rats, injury was ameliorated by Gallic acid treatment and in silico approaches also inhibit the cerebrotoxic protein function by targeting on active sites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Praveen Kumar, P.& Madhuri, D.& Siva Sankar Reddy, L.& Dastagiri Reddy, Y.& Somasekhar, G.& Sirisha, N. V. L.…[et al.]. 2021. A new cerebral ischemic injury model in rats, preventive effect of gallic acid and in silico approaches. Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.5204-5213.
https://search.emarefa.net/detail/BIM-1410600
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Praveen Kumar, P.…[et al.]. A new cerebral ischemic injury model in rats, preventive effect of gallic acid and in silico approaches. Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.5204-5213.
https://search.emarefa.net/detail/BIM-1410600
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Praveen Kumar, P.& Madhuri, D.& Siva Sankar Reddy, L.& Dastagiri Reddy, Y.& Somasekhar, G.& Sirisha, N. V. L.…[et al.]. A new cerebral ischemic injury model in rats, preventive effect of gallic acid and in silico approaches. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.5204-5213.
https://search.emarefa.net/detail/BIM-1410600
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5212-5213
رقم السجل
BIM-1410600
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر