Effect of supplementing fava bean (Vicia faba L.) on ulcerative colitis and colonic mucosal DNA content in rats fed a high-sucrose diet
المؤلف
Iskandarani, Arij Adib Abd Allah
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 6 (30 يونيو/حزيران 2021)، ص ص. 3497-3504، 8ص.
الناشر
تاريخ النشر
2021-06-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Ulcerative colitis (UC) is an inflammatory bowel disease with high morbidity.
acetic acid-induced damage of colonic mucosa in rats is a commonly used experimental animal model of UC.
this research aimed to explore for the first time the ameliorative effect of dietary supplementation with fava bean on the incidence of UC in rats fed with sucrose containing diet.
rats were divided into five groups as follows: G1, control healthy rats; G2, colitic rats; G3, colitic rats fed diets containing 30% sucrose, G4, healthy rats fed diets containing 30% sucrose and G5, colitic rats fed diets containing 30% sucrose supplemented with dried ground fava bean.
colonic injury and inflammation were evaluated through a disturbance of oxidative biomarkers, a significant increase in inflammatory biomarkers and inflammatory cytokines, and histological abnormalities in colonic tissues accompanied by colonic mucosal DNA damage.
Colitic rats fed on sucrose containing diet demonstrated additional histological, biochemical, and DNA alterations in colonic mucosa of rats.
dietary supplementation with dried ground fava bean significantly corrected the impaired oxidative and inflammatory biomarker levels and modulated histological features and DNA alterations.
finally, fava bean attenuated the oxidative damage and colonic injury induced by acetic acid, which confirmed its high anti-oxidant and anti-incendiary properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iskandarani, Arij Adib Abd Allah. 2021. Effect of supplementing fava bean (Vicia faba L.) on ulcerative colitis and colonic mucosal DNA content in rats fed a high-sucrose diet. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3497-3504.
https://search.emarefa.net/detail/BIM-1410839
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iskandarani, Arij Adib Abd Allah. Effect of supplementing fava bean (Vicia faba L.) on ulcerative colitis and colonic mucosal DNA content in rats fed a high-sucrose diet. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3497-3504.
https://search.emarefa.net/detail/BIM-1410839
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iskandarani, Arij Adib Abd Allah. Effect of supplementing fava bean (Vicia faba L.) on ulcerative colitis and colonic mucosal DNA content in rats fed a high-sucrose diet. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3497-3504.
https://search.emarefa.net/detail/BIM-1410839
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3502-3504
رقم السجل
BIM-1410839
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر