Antipyretic activity of Caesalpinia digyna (Rottl.) leaves extract along with phytoconstituent's binding affinity to COX-1, COX-2, and mPGES-1 receptors : in vivo and in silico approaches
المؤلفون المشاركون
Emon, Nazim al-Din
Alam, Safaet
Rudra, Sajib
al-Haydar, Ibrahim Khalil
Farhad, Muhammad
Rana, Md Ezazul Hoque
Ganguly, Amlan
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 9 (30 سبتمبر/أيلول 2021)، ص ص. 5302-5309، 8ص.
الناشر
تاريخ النشر
2021-09-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Caesalpinia digyna (Rottl.) (Family: Fabaceae) is well known for its numerous medicinal values against several human disorders including fever, senile pruritis, diarrhea, tuberculosis, tonic disorder, diabetes, etc.
The current study is intended to investigate the in vivo antipyretic activity of the methanol extract of C.
digyna leaves (MECD) and its carbon-tetrachloride (CTCD) and butanol fraction (BTCD).
Besides, in silico molecular docking and ADME/T profiling of the selective identified bioactive compounds of C.
digyna has been also studied to validate the experimental outcomes and establish a better insight into the possible receptor-ligand interaction affinity.
In vivo antipyretic activity of MECD, CTCD and BTCD were evaluated by employing yeast induced pyrexia technique in mice model and in silico analysis of the identified compounds of C.
digyna has been implemented using PyRx autodock vina, Discovery Studio 2020, UCSF Chimera software and ADME/T online tools.
MECD and BTCD unveiled significant antipyretic activity in dose dependent manner whereas, CTCD failed to exhibit significant antipyretic activity.
Comparing to other test sample, MECD (400 mg/kg; b.w) (p < 0.001) displayed maximum inhibition of pyrexia.
In molecular docking approach, docking score between -6.60 to -10.20 kcal/mol have been revealed.
Besides, in ADME/T analysis, no compound violated the lipiniski's 5 rules and displayed any toxicity.
Biological and computational approaches ascertain the ethno-botanical use of C.
digyna as a good agent against pyrexia and the compounds of C.
digyna are primarily proved as safe.
Hereafter, further analysis is suggested to validate this research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Emon, Nazim al-Din& Alam, Safaet& Rudra, Sajib& Farhad, Muhammad& Rana, Md Ezazul Hoque& Ganguly, Amlan…[et al.]. 2021. Antipyretic activity of Caesalpinia digyna (Rottl.) leaves extract along with phytoconstituent's binding affinity to COX-1, COX-2, and mPGES-1 receptors : in vivo and in silico approaches. Saudi Journal of Biological Sciences،Vol. 28, no. 9, pp.5302-5309.
https://search.emarefa.net/detail/BIM-1411299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Farhad, Muhammad…[et al.]. Antipyretic activity of Caesalpinia digyna (Rottl.) leaves extract along with phytoconstituent's binding affinity to COX-1, COX-2, and mPGES-1 receptors : in vivo and in silico approaches. Saudi Journal of Biological Sciences Vol. 28, no. 9 (2021), pp.5302-5309.
https://search.emarefa.net/detail/BIM-1411299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Emon, Nazim al-Din& Alam, Safaet& Rudra, Sajib& Farhad, Muhammad& Rana, Md Ezazul Hoque& Ganguly, Amlan…[et al.]. Antipyretic activity of Caesalpinia digyna (Rottl.) leaves extract along with phytoconstituent's binding affinity to COX-1, COX-2, and mPGES-1 receptors : in vivo and in silico approaches. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 9, pp.5302-5309.
https://search.emarefa.net/detail/BIM-1411299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5309
رقم السجل
BIM-1411299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر