Amphiphiles capsaicin and triton X-100 regulate the chemotherapy drug colchicine’s membrane adsorption and ion pore formation potency
المؤلف
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 5 (31 مايو/أيار 2021)، ص ص. 3100-3109، 10ص.
الناشر
تاريخ النشر
2021-05-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الملخص EN
Chemotherapy drugs (CDs), e.g.
colchicine derivative thiocolchicoside (TCC) and taxol, have been found to physically bind with lipid bilayer membrane and induce ion pores.
Amphiphiles capsaicin (Cpsn) and tri-ton X-100 (TX100) are known to regulate lipid bilayer physical properties by altering bilayer elasticity and lipid monolayer curvature.
Both CDs and amphiphiles are predicted to physically accommodate alongside lipids in membrane to exert their membrane effects.
The effects of their binary accommodation in the lipid membrane are yet to be known.
Firstly, we have performed experimental studies to inspect whether membrane adsorption of CDs (colchicine or TCC) gets regulated due to any membrane effects of Cpsn or TX100.
We find that the aqueous phase presence of these amphiphiles, known to reduce the membrane stiffness, works towards enhancing the membrane adsorption of CDs.
Our recently patented technology ‘direct detection method’ helps address the membrane adsorption mechanisms.
Secondly, in electrophysiology records, we measured the amphiphile effects on the potency of ion channel induction due to CDs.
We find that amphiphiles increase the CD induced channel induction potency.
Specifically, the membrane conductance, apparently due to the ion channel induction by the TCC, increases substan-tially due to the Cpsn or TX100 induced alterations of the bilayer physical properties.
Thus we may con-clude that the binary presence of CDs and amphiphiles in lipid membrane may influence considerably in CD’s membrane adsorption, as well as the membrane effects, such as ion pore formation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ashraf al-Zamman, Muhammad. 2021. Amphiphiles capsaicin and triton X-100 regulate the chemotherapy drug colchicine’s membrane adsorption and ion pore formation potency. Saudi Journal of Biological Sciences،Vol. 28, no. 5, pp.3100-3109.
https://search.emarefa.net/detail/BIM-1414491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ashraf al-Zamman, Muhammad. Amphiphiles capsaicin and triton X-100 regulate the chemotherapy drug colchicine’s membrane adsorption and ion pore formation potency. Saudi Journal of Biological Sciences Vol. 28, no. 5 (2021), pp.3100-3109.
https://search.emarefa.net/detail/BIM-1414491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ashraf al-Zamman, Muhammad. Amphiphiles capsaicin and triton X-100 regulate the chemotherapy drug colchicine’s membrane adsorption and ion pore formation potency. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 5, pp.3100-3109.
https://search.emarefa.net/detail/BIM-1414491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3109
رقم السجل
BIM-1414491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر