Histological changes in placental rat apoptosis via FasL and cytochrome c by the nano-herbal Zanthoxylum acanthopodium
المؤلفون المشاركون
Situmorang, Putri Cahaya
Ilyas, Syafr al-din
Hutahaean, Salomo
Rosidah, Rosidah
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 5 (31 مايو/أيار 2021)، ص ص. 3060-3068، 9ص.
الناشر
تاريخ النشر
2021-05-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Zanthoxylum acanthopodium has several biological activities, such as antimicrobial, anti-inflammatory, and antioxidant properties.
This strong antioxidant herb can be used as a drug for hypertension.
FasL and cytochrome c expression play roles in the apoptotic pathway in the placenta.
This study focused on the histological change in apoptosis via cytochrome c and Fas ligand expression by investigating whether Zanthoxylum acanthopodium (ZA) fruits affect apoptosis.
The present study consisted of five treatments: Normal pregnant rats (C), Hypertension rats (C + ), hypertension rats + extra virgin olive oil (EVOO) (T1), Hypertension rats + ZA (T2), and hypertension rats + EVOO + ZA (T3).
Hypertension was induced in rats by injecting 3 mlml of 6% NaCl.
Nanoherbal of ZA (100 mg/kg BW) and EVOO (1 ml) were given on the 13th–19th days of pregnancy.
Pregnant rats were dissected on the 20th day of pregnancy by cervical dislocation.
ELISA assays were performed for the analysis of HSP-70 expression.
Immunohistochemistry and TUNEL assays were used to analyse the histological changes in placental tis- sue.
The results showed that cytochrome c and FasL protein exposure levels in the labyrinth, basal, and yolk sac zones were increased during hypertensive pregnancy (P < 0.0001) in rats.
The administration of nanoherbal of ZA decreased the expression of cytochrome c and FasL.
A significant difference was found in the combination of nanoherbal of ZA and EVOO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Situmorang, Putri Cahaya& Ilyas, Syafr al-din& Hutahaean, Salomo& Rosidah, Rosidah. 2021. Histological changes in placental rat apoptosis via FasL and cytochrome c by the nano-herbal Zanthoxylum acanthopodium. Saudi Journal of Biological Sciences،Vol. 28, no. 5, pp.3060-3068.
https://search.emarefa.net/detail/BIM-1414508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Situmorang, Putri Cahaya…[et al.]. Histological changes in placental rat apoptosis via FasL and cytochrome c by the nano-herbal Zanthoxylum acanthopodium. Saudi Journal of Biological Sciences Vol. 28, no. 5 (2021), pp.3060-3068.
https://search.emarefa.net/detail/BIM-1414508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Situmorang, Putri Cahaya& Ilyas, Syafr al-din& Hutahaean, Salomo& Rosidah, Rosidah. Histological changes in placental rat apoptosis via FasL and cytochrome c by the nano-herbal Zanthoxylum acanthopodium. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 5, pp.3060-3068.
https://search.emarefa.net/detail/BIM-1414508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
رقم السجل
BIM-1414508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر