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The potential preventive role of vitamin C against structural changes in male rats' liver induced by tramadol
العناوين الأخرى
الدور الوقائي المحتمل للفيتامين C ضد التغيرات البنيوية الكبدية الناجمة عن المعالجة باستخدام Tramadol عند ذكور الفئران
المؤلفون المشاركون
Ahmad, Rana Mustafa
al-Izzu, Nadwa Subhi
al-Hubayti, Abd al-Jabbar Yasin Muhammad
المصدر
Journal of the Arab Board of Health Specializations
العدد
المجلد 22، العدد 1 (30 يونيو/حزيران 2021)، ص ص. 26-32، 7ص.
الناشر
المجلس العربي للاختصاصات الصحية
تاريخ النشر
2021-06-30
دولة النشر
سوريا
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective: The aim of the study is to detect the toxic effects of tramadol on the histological structure of the liver tissue in adult male albino rats and the possible protective role of vitamin C.
Methods: Thirty adult albino rats were used in this study.
The animals were divided into three equal groups:Group A (Control group): In this group animals were injected with distilled water.
Group B (Tramadol treated group, TGI): Animals were given tramadol in a dose of 50 mg/kg daily.
Group C (Group treated with tramadol plus vitamin C, TGII): Animals were given vitamin C 100 mg/Kg half hour prior to tramadol injection in the same dose as in TGI.
All animals were injected intraperitoneally (I.P) for four weeks.
At the end of the experiment, the rats were killed after anaesthetized by ether then the liver was removed and preserved in a fixative and processed to get paraffin wax block and prepared for microscopic examination.
Results: Histological changes has been found in the tramadol treated group TGI compared to the control group including dilatation and congestion of central vein, portal vein and sinusoids.
Also increased infiltration of mononuclear inflammatory cells (MNCs) with prominent kupffer cells hyperplasia.
In addition, the hepatocytes showed vacoulation with bile duct hyperplasia and increased deposition of collagen fibers in liver parenchyma mainly around portal area.
All these structural changes in liver were ameliorated by giving vitamin C prior to tramadol.
Conclusions: Tramadol caused structural changes in liver tissues and the addition of vitamin C ameliorates these changes.
of toxic metabolites in the body, increase the risk for its toxico-kinetics effects and/or decrease the clearance of tramadol, thus increasing its toxicity.7 Vitamin C, a water-soluble vitamin is as potent micronutrient that has two main functions as an antioxidant and as an enzyme cofactor.8 It performances as a biological antioxidant that scavenges free radicals and other reactive nitrogen and oxygen species by donating an electron to free radical species there by interrupting the radical chain reaction.9 So, even in small amounts; it can protect indispensable molecules in the body, as proteins, lipids and nucleic acids against oxidative harm.10
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad, Rana Mustafa& al-Hubayti, Abd al-Jabbar Yasin Muhammad& al-Izzu, Nadwa Subhi. 2021. The potential preventive role of vitamin C against structural changes in male rats' liver induced by tramadol. Journal of the Arab Board of Health Specializations،Vol. 22, no. 1, pp.26-32.
https://search.emarefa.net/detail/BIM-1419168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmad, Rana Mustafa…[et al.]. The potential preventive role of vitamin C against structural changes in male rats' liver induced by tramadol. Journal of the Arab Board of Health Specializations Vol. 22, no. 1 (2021), pp.26-32.
https://search.emarefa.net/detail/BIM-1419168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad, Rana Mustafa& al-Hubayti, Abd al-Jabbar Yasin Muhammad& al-Izzu, Nadwa Subhi. The potential preventive role of vitamin C against structural changes in male rats' liver induced by tramadol. Journal of the Arab Board of Health Specializations. 2021. Vol. 22, no. 1, pp.26-32.
https://search.emarefa.net/detail/BIM-1419168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 31-32
رقم السجل
BIM-1419168
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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