Comparison between fructose amine and hemoglobin A1C level to evaluate glycemic control in Sudanese diabetic control

الملخص EN

Background: Diabetes mellitus (DM), commonly referred to as diabetes, is a group of metabolic diseases with high blood sugar levels over a prolonged period, and is one of the most severe and frequent human disorders.

Fructosamine is a generic name given to a compound known as plasma protein ketoamines.

Fructosamine together with glycated haemoglobin (HbA1c) are used to monitor the state of hyperglycaemia in diabetics.

Objectives: This study aimed to compare between HeamoglobinA1c and Fructosamine in Sudanese diabetic patients in Omdurman Teaching Hospital and Diabetic and Endocrine center in Bahri.

Materials and Methods: This is a cross-sectional study.

Automated colorimetric determination of fructosamine for each of the 50 blood samples of the study group was carried out according to specific procedure.

Latex enhanced immuno-assay method for hemoglobinA1c (HbA1c) determination based on the interaction between antigen molecules (HbA1c) and HbA1c specific c antibodies coated on latex beads was carried out according to a specific procedure.

Control group criteria should be clear because it is confused.

Results: HbA1c% and Fructose amine were measured on the same sample in 50 diabetic patients.

There is a significantly direct positive correlation between levels of fructose amine (mmol/L) and HbA1c% among the studied group (P-value = 0.001 < 0.05).

Sensitivity and specificity of fructosamine and HbA1c to detect blood glucose.

hemoglobin A1C has (86%) sensitivity and (25%) specificity while fructosamine has (63%) sensitivity and (55%) specificity.

Conclusion: In diabetes serum fructosamine assay can better reflect average blood glucose concentration over the previous 2-3 weeks and HbA1c is better reflective over the previous 8-10 weeks there for fructosamine can be used as routine test while HbA1C as a first -line screening test.