Effect of acute and chronic morphine intoxication on the Activity of the GABA shunt in some parts of the rat brain

الملخص EN

The activities of the enzymes of GABA catabolism and tricarboxylic acid cycle (TCA) were studied in brain regions of rats underwent acute and chronic morphine intoxication.

The changes observed in the GABA metabolism and TCA differed in the brain regions were tested and depended on the dosage and duration of morphine injections.

The possible explanation of the shifts observed is likely to be associated with indirect adaptation of the GABAergic neurons in the brain regions differing in the opioid receptors contents to morphine injections.