The efficacy of N-acetilcysteine for the treatment of the metamfetamin-addicted patients under methadon therapy :
المؤلفون المشاركون
Assarian, Fatimah
Sehat, Mojtaba
Karami, Farzaneh
Ghoreishi, Fatimah Sadat
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 22، العدد 7 (31 يوليو/تموز 2020)، ص ص. 1-8، 8ص.
الناشر
تاريخ النشر
2020-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background: Methamphetamine dependence is a growing global problem.
Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence.
One of the alternatives to manage this addiction is the use of N acetylcysteine (NAC) due to its capacity to restore homeostasis in the brain glutamate systems disrupted in addiction and its ability to reduce craving and the risk of relapse.
Methods: Methamphetamine-dependentvolunteersundermethadonetreatment(n= 38) wererandomizedtoreceivedailydosesof 1200 mg of NAC, or placebo.
The participants were followed for 12 weeks (two visits weekly).
Craving and Beck Inventory Depression (BDI) was determined at the beginning of the study and also after one month, two months, and three months.
Addiction severity index (ASI) was recorded at the beginning of the study and after three months.
The data were analyzed via SPSS version 16.0 (SPSS Inc.
Chicago, Illinios, USA) Results: The mean score of craving and BDI reduced after two months with NAC treatment.
ASI (e.g., substance, familial, and psy- chiatric categories) was significantly reduced at the end of the study in the NAC group compared to placebo (P < 0.001).
The success of the treatment in groups of NAC and placebo were 84% and 73%, respectively (P = 0.001).
63.2% of the NAC group patients avoided substance use for more than a month, but this was 10.5% in the placebo group (P = 0.001).
Conclusions: The NAC showed good efficacy in suppressing methamphetamine craving, addiction severity index, and depression.
It may be a useful pharmacological treatment for methamphetamine dependency.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karami, Farzaneh& Assarian, Fatimah& Ghoreishi, Fatimah Sadat& Sehat, Mojtaba. 2020. The efficacy of N-acetilcysteine for the treatment of the metamfetamin-addicted patients under methadon therapy :. Iranian Red Crescent Medical Journal،Vol. 22, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-1430492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sehat, Mojtaba…[et al.]. The efficacy of N-acetilcysteine for the treatment of the metamfetamin-addicted patients under methadon therapy :. Iranian Red Crescent Medical Journal Vol. 22, no. 7 (Jul. 2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1430492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karami, Farzaneh& Assarian, Fatimah& Ghoreishi, Fatimah Sadat& Sehat, Mojtaba. The efficacy of N-acetilcysteine for the treatment of the metamfetamin-addicted patients under methadon therapy :. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 7, pp.1-8.
https://search.emarefa.net/detail/BIM-1430492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 7-8
رقم السجل
BIM-1430492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر