Relationship of breast cancer susceptibility with rs6257 and rs6258 polymorphisms in the SHBG gene
المؤلفون المشاركون
Shirzad, Sarah
Fard, Zahrah Tahmasebi
Jamaldini, Sayyid Hamid
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 22، العدد 10 (31 أكتوبر/تشرين الأول 2020)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2020-10-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background: Breast cancer is a hormone-dependent malignancy.
Sex hormone-binding globulin (SHBG) is the main transport binding protein for sex steroid hormones in plasma and regulates their accessibility to target cells.
Objectives: The present study aimed to assess the relationship of breast cancer risk with rs6257 and rs6258 polymorphisms in the SHBG gene.
Methods: This case-control study was conducted on 100 breast cancer patients and 100 healthy control subjects.
After extracting DNA from peripheral blood, Genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method.
The data were analyzed in SPSS software using the chi-square test and logistic regression to distinguish the difference between the cases and controls in terms of the distribution of allele types and genotypes.
Results: The frequencies of Rs6257 were 78%, 17%, 5% in the case group and 88%, 7%, and 5% in control groups for TT, CC, and CT genotypes respectively.
The rs6257 CC genotype showed about a 2.721-fold increase in breast cancer (P=0.030, OR:2.721, CI95%:1.075-6.887).
This genotype was reversely associated with age, body mass index, menopausal status, and breast cancer.
Nonetheless, Rs6258 had no significant correlation with breast cancer risk or other demographic factors.
Conclusion: As evidenced by the obtained results, the rs6257 polymorphism may be a useful biomarker associated with breast cancer risk in Iranian women.
To confirm the findings of the present study, larger studies are needed in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shirzad, Sarah& Fard, Zahrah Tahmasebi& Jamaldini, Sayyid Hamid. 2020. Relationship of breast cancer susceptibility with rs6257 and rs6258 polymorphisms in the SHBG gene. Iranian Red Crescent Medical Journal،Vol. 22, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-1430677
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shirzad, Sarah…[et al.]. Relationship of breast cancer susceptibility with rs6257 and rs6258 polymorphisms in the SHBG gene. Iranian Red Crescent Medical Journal Vol. 22, no. 10 (Oct. 2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1430677
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shirzad, Sarah& Fard, Zahrah Tahmasebi& Jamaldini, Sayyid Hamid. Relationship of breast cancer susceptibility with rs6257 and rs6258 polymorphisms in the SHBG gene. Iranian Red Crescent Medical Journal. 2020. Vol. 22, no. 10, pp.1-6.
https://search.emarefa.net/detail/BIM-1430677
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-1430677
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر