Effectiveness of optical coherence tomography angiography (OCT-A) in staging glaucoma
المؤلفون المشاركون
Li, Xilong
Adams Huet, Beverley
Deng, Ted
al-Salim, Munsif
Nurani, Sahar
Yang, Alex
Kooner, Karanjit S.
المصدر
Journal of the Royal Medical Services
العدد
المجلد 29، العدد 2 (31 أغسطس/آب 2022)، ص ص. 38-50، 13ص.
الناشر
الخدمات الطبية الملكية الأردنية
تاريخ النشر
2022-08-31
دولة النشر
الأردن
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Objectives: To analyze whether vessel density or nerve fiber layer thicknes (structural properties) obtained by optical coherence tomography angiography (OCT-A) could differentiate between healthy controls and patients with ocular hypertension or mild, moderate and severe glaucoma.
In addition, to determine if vessel density or nerve fiber layer thickness is most helpful in detecting early glaucomatous damage.
Methods: In this retrospective study, we selected 69 healthy controls, 36 patients with ocular hypertension, and 91 with primary open-angle glaucoma (54 mild, 25 moderate, and 12 severe).
One eye was randomly selected per patient.
Patients were excluded if they were < 18 years, had secondary glaucoma, OCT-A signal strength index < 40, refractive errors > ± 5 D, vision worse than 20/40, or only one functional eye.
Collected data included: age, ethnicity, gender, family history of glaucoma, intraocular pressure, visual fields, cup/disc ratio, and OCT-A macular and optic nerve head scanning parameters.
Results: Whole image optic nerve head and macular vessel density both decreased as the glaucoma progressed, from ocular hypertension to severe stage, 56.7% to 43.1% and 49.0% to 43.4%, respectively (p<0.01).
Similarly, average nerve fiber layer thickness decreased from, 92.0μm to 60.1μm (p<0.01) in patients with ocular hypertension to those with severe glaucoma.
Both structural properties and vessel density were equally effective at determining glaucoma stage.
Between healthy controls and patients with ocular hypertension, we noticed structural property differences, but no vessel density differences.
Conclusion: Both optic nerve head and macular vessel density and structural properties assessed by OCT-A may provide an objective measure of glaucomatous damage in the eye.
In addition, we have found that structural damage may occur before vessel density damage in ocular hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Salim, Munsif& Yang, Alex& Nurani, Sahar& Deng, Ted& Li, Xilong& Adams Huet, Beverley…[et al.]. 2022. Effectiveness of optical coherence tomography angiography (OCT-A) in staging glaucoma. Journal of the Royal Medical Services،Vol. 29, no. 2, pp.38-50.
https://search.emarefa.net/detail/BIM-1430829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Salim, Munsif…[et al.]. Effectiveness of optical coherence tomography angiography (OCT-A) in staging glaucoma. Journal of the Royal Medical Services Vol. 29, no. 2 (Aug. 2022), pp.38-50.
https://search.emarefa.net/detail/BIM-1430829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Salim, Munsif& Yang, Alex& Nurani, Sahar& Deng, Ted& Li, Xilong& Adams Huet, Beverley…[et al.]. Effectiveness of optical coherence tomography angiography (OCT-A) in staging glaucoma. Journal of the Royal Medical Services. 2022. Vol. 29, no. 2, pp.38-50.
https://search.emarefa.net/detail/BIM-1430829
نوع البيانات
مقالات
لغة النص
الإنجليزية
رقم السجل
BIM-1430829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر