The role of lipoprotein (a) and dyslipidemia in diabetic retinopathy in a sample of Syrian patients with type 2 diabetes mellitus
العناوين الأخرى
دور البروتين الشحمي (a) و اضطرابات شحميات الدم في اعتلال الشبكية السكري عند عينة من السوريين المصابين بالنمط الثاني للداء السكري
المؤلفون المشاركون
Umran, Lama MS.
al-Urfi, Zaynab
Barakat, Yusuf A.
المصدر
Journal of the Arab Board of Health Specializations
العدد
المجلد 23، العدد 1 (30 يونيو/حزيران 2022)، ص ص. 28-34، 7ص.
الناشر
المجلس العربي للاختصاصات الصحية
تاريخ النشر
2022-06-30
دولة النشر
سوريا
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objective: Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age group.
Detecting DR-related risk factors is the best early prevention strategy.
The purpose of this study was to investigate the association between lipoprotein (a) [)Lp(a)] and DR occurrence.
Additionally, the study aimed to determine the relationship between dyslipidemia and DR incidence in a sample of Syrian patients with type 2 diabetes mellitus (T2DM).
Methods: One hundred and twenty-two participants were included in this case–control study.
Thirty-one participants were in the control group, 61 were in the T2DM with DR (DM and DR) case group, and 30 were in the T2DM without DR group.
Fundus examination was performed to assess the existence and degree of retinopathy.
Lp(a), lipid profile component, fasting glucose, glycated hemoglobin (HbA1c) were measured.
Results: Lp(a), total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein cholesterol (LDL-C), and nonhigh-density lipoprotein cholesterol (non-HDL-C) were significantly higher in the DM and DR case group compared to the other groups.
HDL-C was the lowest in the DM and DR group (P < 0.001).
Lp(a) exhibited significant positive correlations with body mass index, blood pressure, TAG, TC, LDL-C, non-HDL-C, and fasting plasma glucose; however, it had a negative correlation with HDL-C.
The odds ratio of non-HDL/HDL was highest, followed by non-HDL after adjusting for Lp(a).
The best cut-off point of Lp(a) for predicting DR assessed by receiver operating characteristic curve was 36.1 mg/dL (area under curve 0.772).
Conclusions: Our findings suggest that Lp(a) and lipid profile components were risk factors for DR incidence in T2DM patients.
Non-HDL-C/HDL-C ratio was the best lipid predictor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Umran, Lama MS.& al-Urfi, Zaynab& Barakat, Yusuf A.. 2022. The role of lipoprotein (a) and dyslipidemia in diabetic retinopathy in a sample of Syrian patients with type 2 diabetes mellitus. Journal of the Arab Board of Health Specializations،Vol. 23, no. 1, pp.28-34.
https://search.emarefa.net/detail/BIM-1431366
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Umran, Lama MS.…[et al.]. The role of lipoprotein (a) and dyslipidemia in diabetic retinopathy in a sample of Syrian patients with type 2 diabetes mellitus. Journal of the Arab Board of Health Specializations Vol. 23, no. 1 (2022), pp.28-34.
https://search.emarefa.net/detail/BIM-1431366
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Umran, Lama MS.& al-Urfi, Zaynab& Barakat, Yusuf A.. The role of lipoprotein (a) and dyslipidemia in diabetic retinopathy in a sample of Syrian patients with type 2 diabetes mellitus. Journal of the Arab Board of Health Specializations. 2022. Vol. 23, no. 1, pp.28-34.
https://search.emarefa.net/detail/BIM-1431366
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 34
رقم السجل
BIM-1431366
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر