A comprehensive insight into the role of zinc deficiency in the renin-angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients
المؤلفون المشاركون
Abd al-Rahman, Fatimah G.
al-Bindari, Riham N.
al-Harbi, Fadiyah Ahmad
al-Hamrani, Sultan Qalit
Mégarbane, Bruno
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 6 (30 يونيو/حزيران 2021)، ص ص. 3540-3547، 8ص.
الناشر
تاريخ النشر
2021-06-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Hypozincemia is prevalent in severe acute respiratory syndrome coronavirus-2 (SARS-COV-2)-infected patients and has been considered as a risk factor in severe coronavirus disease-2019 (COVID-19).
Whereas zinc might affect SARS-COV-2 replication and cell entry, the link between zinc deficiency and COVID-19 severity could also be attributed to the effects of COVID-19 on the body metabolism and immune response.
Zinc deficiency is more prevalent in the elderly and patients with underlying chronic diseases, with established deleterious consequences such as the increased risk of respiratory infection.
We reviewed the expected effects of zinc deficiency on COVID-19-related pathophysiological mechanisms focusing on both the renin–angiotensin and kinin-kallikrein systems.
Mechanisms and effects were extrapolated from the available scientific literature.
Zinc deficiency alters angiotensin-converting enzyme-2 (ACE2) function, leading to the accumulation of angiotensin II, des-Arg9-bradykinin and Lysdes- Arg9-bradykinin, which results in an exaggerated pro-inflammatory response, vasoconstriction and pro-thrombotic effects.
Additionally, zinc deficiency blocks the activation of the plasma contact system, a protease cascade initiated by factor VII activation.
Suggested mechanisms include the inhibition of Factor XII activation and limitation of high-molecular-weight kininogen, prekallikrein and Factor XII to bind to endothelial cells.
The subsequent accumulation of Factor XII and deficiency in bradykinin are responsible for increased production of inflammatory mediators and marked hypercoagulability, as typically observed in COVID-19 patients.
To conclude, zinc deficiency may affect both the renin–angiotensin and kinin-kallikrein systems, leading to the exaggerated inflammatory manifestations characteristic of severe COVID-19.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jawdah, Ahmad S.& Abd al-Rahman, Fatimah G.& al-Bindari, Riham N.& al-Harbi, Fadiyah Ahmad& al-Hamrani, Sultan Qalit& Mégarbane, Bruno. 2021. A comprehensive insight into the role of zinc deficiency in the renin-angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3540-3547.
https://search.emarefa.net/detail/BIM-1431467
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jawdah, Ahmad S.…[et al.]. A comprehensive insight into the role of zinc deficiency in the renin-angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3540-3547.
https://search.emarefa.net/detail/BIM-1431467
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jawdah, Ahmad S.& Abd al-Rahman, Fatimah G.& al-Bindari, Riham N.& al-Harbi, Fadiyah Ahmad& al-Hamrani, Sultan Qalit& Mégarbane, Bruno. A comprehensive insight into the role of zinc deficiency in the renin-angiotensin and kinin-kallikrein system dysfunctions in COVID-19 patients. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3540-3547.
https://search.emarefa.net/detail/BIM-1431467
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3545-3547
رقم السجل
BIM-1431467
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر