Differences in prognosis between synchronous and metachronous metastatic breast cancer
العناوين الأخرى
الاختلاف في الإنذارية بين النقائل المتواقتة و اللاحقة في سرطان الثدي
المؤلفون المشاركون
المصدر
Damascus University Journal for Medical Sciences
العدد
المجلد 37، العدد 3 (30 سبتمبر/أيلول 2021)، ص ص. 1-10، 10ص.
الناشر
تاريخ النشر
2021-09-30
دولة النشر
سوريا
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and aim: There are many previous articles that studied the relationship of prognostic factors with metastatic breast cancer, as they provided us with important information on factors related to the nature of the tumor itself, and others related to the patient.
Also, the prognostic factors differ with the nature of the metastasis and its time of occurrence.
We aim to identify the differences in prognosis between synchronous and metachronous metastatic breast cancer.
Patients and Methods: We identified women in Al-Bairouni-University Hospital with metastatic breast cancer (MBC) diagnosed between January 2008 and December 2010.
1st time to progression (TTP) was calculated for metachronous versus synchronous patients.
Survival rates and median TTP After metastasis diagnosis were determined using the Kaplan-Meier method and prognostic factors were determined in a Cox Proportional Hazard model.
Results: We identified 350 patients, median TTP (mTTP) was longer for synchronous versus metachronous MBC (14 months for SMBC versus 8 months for MMBC) (P=0.0001).
While TTP for patients with synchronous MBC is longer in positive hormonal receptor HR= 0.63 (0.40-0.99) (P = 0, 046) and was affected negatively by high grade of tumor HR= 3.83 (1.12-13.03) (P = 0.032).
Otherwise, TTP for patient with metachronous MBC is to a larger extent associated with factors intrinsic to the patients and tumor such as performance status HR=3.6 (1.38-9.34) (P =0.009), high grade of tumor HR=2.30 (1.03-5.11) (P = 0.042) and high number of metastatic site HR=7.12(0.90-56.30) (P =0.063).
Conclusion: TTP with synchronous metastases is longer than with metachronous metastases and the prognostic factors affect differently between two groups which requires special approach to each of them in terms of prognosis and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Muhammad& Sifu, Mahir. 2021. Differences in prognosis between synchronous and metachronous metastatic breast cancer. Damascus University Journal for Medical Sciences،Vol. 37, no. 3, pp.1-10.
https://search.emarefa.net/detail/BIM-1431622
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Muhammad& Sifu, Mahir. Differences in prognosis between synchronous and metachronous metastatic breast cancer. Damascus University Journal for Medical Sciences Vol. 37, no. 3 (2021), pp.1-10.
https://search.emarefa.net/detail/BIM-1431622
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Muhammad& Sifu, Mahir. Differences in prognosis between synchronous and metachronous metastatic breast cancer. Damascus University Journal for Medical Sciences. 2021. Vol. 37, no. 3, pp.1-10.
https://search.emarefa.net/detail/BIM-1431622
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 10
رقم السجل
BIM-1431622
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر