Surgical resection of hepatocellular carcinoma in compensated cirrhotic liver : the benefits and selection criteria
المؤلفون المشاركون
Dush, Wail Muhyi al-Din Ahmad
al-Zayn, Juhaynah Ahmad
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 14، العدد 4 (31 ديسمبر/كانون الأول 2019)، ص ص. 225-251، 27ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2019-12-31
دولة النشر
السودان
عدد الصفحات
27
التخصصات الرئيسية
الملخص EN
Background: Hepatocellular carcinoma (HCC) represents a fifth of common malignancies, with an annual diagnosis of 750,000 new cases.
It is the third cause of cancer deaths worldwide.
The cirrhotic liver is a leading cause of HCC with the annual conversion rate to HCC in the range of 2–6 %.
The underlying liver cirrhosis limits certain treatment modalities that potentially further aggravates liver dysfunction.
Over the past decade, there were substantial improvements in the HCC resection techniques that has resulted in the reduction of operative mortality.
This allowed doing major hepatectomy in cirrhotic patients who are suitable for liver transplantation but lacking availability of cadaveric or living donors.
Also, patients who have multi-focal HCC underlying cirrhosis which render them unsuitable for liver transplantation due to its extension beyond Milan criteria.
Objective: The objective of this study was to assess the benefits and selection criteria of HCC surgical resection within child–Turcotte–Pugh score (CTP) A and B liver cirrhosis to achieve the best surgical outcomes.
Methods: We performed a literature search within English written trials using PubMed and MEDLINE reviews databases from 1986 to 2017.
One hundred fifty studies are included in this review evaluating various parameters including HCC and compensated cirrhosis prevalence, pathogenesis, clinical presentation, and diagnostic methods.
Furthermore, we have compared oncological hepatic resection with other modalities like transarterial chemoembolization, liver transplantation, embolization of the portal vein, laparoscopic hepatic resection, and ALPPS technique.
Principles of surgical hepatectomy and postoperative complications are also presented in this review.
onclusion: This review has demonstrated that hepatic cirrhosis complicated by portal hypertension is not an absolute contraindication for HCC resection.
Furthermore, elective surgery must not be directed exclusively to CTP A cirrhosis but it can be applied to highly selected patients who had suffered from advanced hepatic cirrhosis.
If multifocal HCC underlying hepatic cirrhosis was unsuitable for liver transplantation, hepatectomy can be carried out to increase the tumor cure chances, prevent it’s recurrences, and lead to significant survival rate improvement.
The degree of cirrhosis significantly affects the decision of primary hepatic carcinoma treatment and it’s prognosis.
The interdisciplinary assessment of liver function by surgeons, hepatologists, anesthesiologists, and specialists of critical care are essential for maximum critical stabilization of the patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dush, Wail Muhyi al-Din Ahmad& al-Zayn, Juhaynah Ahmad. 2019. Surgical resection of hepatocellular carcinoma in compensated cirrhotic liver : the benefits and selection criteria. Sudan Journal of Medical Sciences،Vol. 14, no. 4, pp.225-251.
https://search.emarefa.net/detail/BIM-1435880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dush, Wail Muhyi al-Din Ahmad& al-Zayn, Juhaynah Ahmad. Surgical resection of hepatocellular carcinoma in compensated cirrhotic liver : the benefits and selection criteria. Sudan Journal of Medical Sciences Vol. 14, no. 4 (2019), pp.225-251.
https://search.emarefa.net/detail/BIM-1435880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dush, Wail Muhyi al-Din Ahmad& al-Zayn, Juhaynah Ahmad. Surgical resection of hepatocellular carcinoma in compensated cirrhotic liver : the benefits and selection criteria. Sudan Journal of Medical Sciences. 2019. Vol. 14, no. 4, pp.225-251.
https://search.emarefa.net/detail/BIM-1435880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 239-251
رقم السجل
BIM-1435880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر