6-Shogaol attenuated ethylene glycol and aluminium chloride induced urolithiasis and renal injuries in rodents
المؤلفون المشاركون
Imam, Faisal
Abd al-Salam, Aftab Ahmad
Kazimi, Umran
Qadi, Anwar al-Abidin al-Din Muhsin
al-Abbasi, Fahd A.
al-Harbi, Khalid Sad
al-Zari, Sami Ibrahim
Zafar, Amidu al-Zafar
Muhammad Afzal
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 6 (30 يونيو/حزيران 2021)، ص ص. 3418-3423، 6ص.
الناشر
تاريخ النشر
2021-06-30
دولة النشر
السعودية
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The 6-shogaol, is a flavanone type flavonoid that is abundant in citrus fruit and has a wide range of pharmacological effects.
the present study attempted to evaluate the antiurolithic effect of 6-shogaol on ethylene glycol (EG) and ammonium chloride (AC)-induced experimental urolithiasis in rats.
The efficacy of 6- shogaol 50 mg/kg and 100 mg/kg was studied in EG 0.75% (V/V) and AC 1% (W/V) experimentally induced urolithiasis in rats for 21 days.
the weight difference, urine volume, the levels of calcium, phosphate, magnesium, oxalate and uric acid in urine was observed.
the blood urea nitrogen, creatinine, uric acid in serum and levels of malondialdehyde (MDA) and glutathione (GSH) were also measured.
histopathological analyses in kidneys were also performed.
The rats weights were higher in the 6- shogaol groups than the urolithiasis group.
EG caused a significant increase in serum creatinine (p < 0.05), BUN (P < 0.001), and uric acid (p < 0.01) while treatment with Cystone (750 mg/kg), and 6- shogaol (50 and 100 mg/kg) showed the significant reduction in increased serum levels of creatinine (p < 0.001), uric acid (p < 0.01) and BUN (p < 0.001).
Administration of EG and AC showed statistically significant (p < 0.001) elevated levels of MDA and reduction in GSH levels.
Treatment of Cystone (750 mg/kg), and 6-shogaol (50 and 100 mg/kg) significantly (p < 0.001) reduced MDA levels and an increase GSH levels as compared to EG and AC-treated group.
the histological findings further attested antiurolithiatic properties of 6-shogaol.
the present study attributed clinical shreds of evidence first time that claiming the significant antiurolithic effect of 6-shogaol and could be a cost-effective candidate for the prevention and treatment of urolithiasis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kazimi, Umran& Qadi, Anwar al-Abidin al-Din Muhsin& Abd al-Salam, Aftab Ahmad& al-Abbasi, Fahd A.& Imam, Faisal& al-Harbi, Khalid Sad…[et al.]. 2021. 6-Shogaol attenuated ethylene glycol and aluminium chloride induced urolithiasis and renal injuries in rodents. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3418-3423.
https://search.emarefa.net/detail/BIM-1437457
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kazimi, Umran…[et al.]. 6-Shogaol attenuated ethylene glycol and aluminium chloride induced urolithiasis and renal injuries in rodents. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3418-3423.
https://search.emarefa.net/detail/BIM-1437457
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kazimi, Umran& Qadi, Anwar al-Abidin al-Din Muhsin& Abd al-Salam, Aftab Ahmad& al-Abbasi, Fahd A.& Imam, Faisal& al-Harbi, Khalid Sad…[et al.]. 6-Shogaol attenuated ethylene glycol and aluminium chloride induced urolithiasis and renal injuries in rodents. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3418-3423.
https://search.emarefa.net/detail/BIM-1437457
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3423
رقم السجل
BIM-1437457
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر