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Protective role of TIRAP functional variant against development of coronary artery disease
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 28، العدد 6 (30 يونيو/حزيران 2021)، ص ص. 3548-3552، 5ص.
الناشر
تاريخ النشر
2021-06-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Coronary artery disease (CAD) is the leading cause of sudden death worldwide.
inflammation is proved to be an important player in development of the CAD.
inflammation is directly regulated by the toll like receptors (TLRs).
susceptibility of CAD is influenced by genetic variations within TLRs and the proteins involved in its signaling cascade.
the TIRAP/MAL {TIR domain containing adaptor protein / MyD88 (myeloid differentiation primary response gene 88) adaptor-like} exhibits maximum genetic variations of all adaptor proteins involved in TLR signaling cascade.
susceptibility to a number of diseases can be influenced due to presence of S180L single nucleotide polymorphism (SNP) of TIRAP/MAL.
This study was conducted to investigate the functional role of this well characterized S180L polymorphism on susceptibility to CAD among Pakistani patients.
a total of 146 Pakistani CAD patients and 147 controls were genotyped by amplification refractory mutation system-polymerase chain reaction (ARMS-PCR) and the data was analyzed by using 2-tailed Chi square (x2) test.
the p value _ 0.05 was considered to be significant.
significantly high frequency of homozygous L180L genotype was observed among healthy subjects as compared to the CAD patients [24 (16%) vs 7 (5%); x2 11.85; p = 0.003].
moreover, the allele frequency of the minor allele; 180L was observed to be significantly higher among controls than the CAD patients, having same direction of association [156 (53%) vs 131 (45%); OR (95% CI) = 0.7198 (0.520–0.996); p < 0.05).
our results indicate that protective effect of L180L; a coding variant of TIRAP/MAL against CAD is discernible.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nurin, Mamunah& Umran, Muhammad& Bashir, Muhammad Amjad& Gul, Sana& al-Khurayji, Afrah Fahd& al-Umar, Sulayman Yusuf…[et al.]. 2021. Protective role of TIRAP functional variant against development of coronary artery disease. Saudi Journal of Biological Sciences،Vol. 28, no. 6, pp.3548-3552.
https://search.emarefa.net/detail/BIM-1437463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nurin, Mamunah…[et al.]. Protective role of TIRAP functional variant against development of coronary artery disease. Saudi Journal of Biological Sciences Vol. 28, no. 6 (2021), pp.3548-3552.
https://search.emarefa.net/detail/BIM-1437463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nurin, Mamunah& Umran, Muhammad& Bashir, Muhammad Amjad& Gul, Sana& al-Khurayji, Afrah Fahd& al-Umar, Sulayman Yusuf…[et al.]. Protective role of TIRAP functional variant against development of coronary artery disease. Saudi Journal of Biological Sciences. 2021. Vol. 28, no. 6, pp.3548-3552.
https://search.emarefa.net/detail/BIM-1437463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 3551-3552
رقم السجل
BIM-1437463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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