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The association of lymphocyte count, CRP, D-Dimer, and LDH with severe coronavirus disease 2019 (COVID-19) : a meta-analysis
المؤلفون المشاركون
Ali, al-Miqdad H. M.
Muhammad, Sagad Umar Ubayd
al-Khidr, Ibrahim H. E.
al-Bathani, Muhammad al-Ata Hasan
Ibrahim, Abazr A. H.
al-Hasan, al-Mutasim B. E.
Salman, Muhammad Sulayman Tawer
al-Hasan, Mazin A. M.
al-Nil, Mahmud
Abu Zayd, Abd al-Hamid Ibrahim Hasan
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 15، العدد 2 (s) (30 يونيو/حزيران 2020)، ص ص. 9-21، 13ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2020-06-30
دولة النشر
السودان
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background: The rapid progression of Coronavirus disease 2019 (COVID-19) and its increasing burden on health systems necessitate the identification of parameters of severe infection to help in monitoring, prognoses and development of treatment algorithms.
Objectives: This review aims to investigate the association of lymphocyte count, CRP, LDH, and D-Dimer with the severity of COVID-19.
Methods: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
The databases of MEDLINE/PubMed, WHO-Virtual Health Library (VHL), and ScienceDirect were used for the systematic search.
Random effects model was used to estimate the pooled standardized mean differences (SMD) with the corresponding 95% confidence interval (CI), using OpenMeta Analyst software.
Results: A total of 11 studies, with 2437 COVID-19 patients, which fulfilled the eligibility criteria were included in the meta-analysis.
The analysis revealed that lymphocyte count was significantly lower in patients with the severe form of COVID-19 (SMD = - 1.025, P value <.001).
Also, the analysis of SMD showed that patients with severe COVID-19 have a significantly higher serum levels of CRP (SMD = 3.363, P value <.001), D-Dimer (SMD = 1.073, P value <.001), and LDH (SMD = 3.345, P value <.001).
Conclusion: Low lymphocyte count and high levels of CRP, LDH, and D-Dimer are associated with severe COVID-19.
These laboratory markers could be used as clinical indicators of worsening illness and poor prognosis of COVID-19.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, al-Miqdad H. M.& Muhammad, Sagad Umar Ubayd& al-Khidr, Ibrahim H. E.& al-Bathani, Muhammad al-Ata Hasan& Ibrahim, Abazr A. H.& al-Hasan, al-Mutasim B. E.…[et al.]. 2020. The association of lymphocyte count, CRP, D-Dimer, and LDH with severe coronavirus disease 2019 (COVID-19) : a meta-analysis. Sudan Journal of Medical Sciences،Vol. 15, no. 2 (s), pp.9-21.
https://search.emarefa.net/detail/BIM-1439501
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, al-Miqdad H. M.…[et al.]. The association of lymphocyte count, CRP, D-Dimer, and LDH with severe coronavirus disease 2019 (COVID-19) : a meta-analysis. Sudan Journal of Medical Sciences Vol. 15, no. 2 (Special issue) (2020), pp.9-21.
https://search.emarefa.net/detail/BIM-1439501
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, al-Miqdad H. M.& Muhammad, Sagad Umar Ubayd& al-Khidr, Ibrahim H. E.& al-Bathani, Muhammad al-Ata Hasan& Ibrahim, Abazr A. H.& al-Hasan, al-Mutasim B. E.…[et al.]. The association of lymphocyte count, CRP, D-Dimer, and LDH with severe coronavirus disease 2019 (COVID-19) : a meta-analysis. Sudan Journal of Medical Sciences. 2020. Vol. 15, no. 2 (s), pp.9-21.
https://search.emarefa.net/detail/BIM-1439501
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 18-21
رقم السجل
BIM-1439501
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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