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Immunological and neurological manifestations of COVID-19 : an intimate relationship
المؤلفون المشاركون
al-Sadiq, S.
al-Sayyid, M.
al-Khidr, A.
Said, M.
Ahmad, R.
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 15، العدد 2 (s) (30 يونيو/حزيران 2020)، ص ص. 111-122، 12ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2020-06-30
دولة النشر
السودان
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background: COVID-19 has superseded all medical scientific challenges in 2020.
It presented with a range of respiratory involvement from the mild upper respiratory tract to severe pneumonia with ARDS.
A percentage of these patients manifested variable neurological presentations expanding the challenges of patients’ assessment, care, and management.
Objective: To discuss the neurological manifestations and the possible immunopathology of COVID-19.
Methods: A literature search was performed in the PubMed database for the relevant articles published in English language between April 9th , 2020 and June 1, 2020.
Few papers were extracted from Google Scholar and pre-print material as well.
The keywords used to perform search included “COVID-19,” “SARS Cov2,” “neurological manifestations,” and “immunology and pathology of COVID-19”.
However, animal studies were excluded in the neurological manifestations, and the final number of literature search outcome was 27 articles.
Results: The immunopathology involves angiotensin-converting enzyme (ACE) receptor 2 and spike protein S1.
COVID-19 has a tremendous affinity to the ACE2 receptor.
The status of secondary hemophagocytic lymphohistiocytosis (sHLH) and the cytokine storm lead to different organ damage and the corresponding clinical manifestations.
The documented neurological manifestations mainly include acute ischemic stroke, hemorrhagic stroke, temporal lobe, thalamic encephalitis, and one case of Guillain-Barre Syndrome, in addition to agitation, headache, and seizures.
Conclusion: Although the intimate relationship between the neurons and the immune activation is the basic concept of COVID-19 immunopathology, the definite routes of entry to the neuronal cells are yet to be disclosed.
Acute stroke, myositis, headache, and meningoencephalitis are the most common types of complications of COVID-19 so far.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sayyid, M.& Ahmad, R.& al-Khidr, A.& Said, M.& al-Sadiq, S.. 2020. Immunological and neurological manifestations of COVID-19 : an intimate relationship. Sudan Journal of Medical Sciences،Vol. 15, no. 2 (s), pp.111-122.
https://search.emarefa.net/detail/BIM-1439590
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sayyid, M.…[et al.]. Immunological and neurological manifestations of COVID-19 : an intimate relationship. Sudan Journal of Medical Sciences Vol. 15, no. 2 (Special issue) (2020), pp.111-122.
https://search.emarefa.net/detail/BIM-1439590
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sayyid, M.& Ahmad, R.& al-Khidr, A.& Said, M.& al-Sadiq, S.. Immunological and neurological manifestations of COVID-19 : an intimate relationship. Sudan Journal of Medical Sciences. 2020. Vol. 15, no. 2 (s), pp.111-122.
https://search.emarefa.net/detail/BIM-1439590
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 121-122
رقم السجل
BIM-1439590
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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