Evaluation of some heavy metals levels in serum of women with breast cancer (premenopausal and postmenopausal)‎ in Baghdad City Iraq

الملخص EN

In this study, the level of heavy metals was examined in the serum of 100 cases for two groups which were 60 cases of breast cancer and 40 not infected cases.

All samples have been Frozen and allowed later to thaw at room temperature.

Inorganic elements (Zn, Cu, Pb) were determined by Flame Atomic orption Spectrophotometry (FAAS).

Data have been analyzed and compared using SPSS-18 and student's T-Test.

The results showed the mean serum zinc concentration of the infected group was (71.7 ± 5.1 and 70.4 ± 5.4 µg/dl) which was highly significantly (P≤0.001) lower than the results of the non-infected group (89.7 ± 10.2 and 97.5 ± 13.2 µg/dl) for Premenopausal and Postmenopausal respectively of each group.

Furthermore, the mean serum copper concentration of the infected group was (157.2 ± 13.9 and 157.4 ±11.9 µg/dl) which was highly significantly (P≤0.001) higher than the results of the non-infected group (122.2 ± 15.5 and 112.2 ± 15.8 µg/dl) for Premenopausal and Postmenopausal respectively of each group.

Moreover, the mean blood lead level was (20.7 ± 2.5 µg/dl and 19.9 ± 1.7 µg/dl) of breast cancer group was significantly higher (P≤0.001) when compared to the other group with (15.1 ± 2.0 µg/dl and 14.6 ± 2.3 µg/dl) Premenopausal and Postmenopausal respectively of each group.

The results of this study indicate that levels of trace metals were little in the breast cancer women in Baghdad city.