The baseline ocular coherence tomography morphology of diabetic macular edema as a prognostic factor for response to anti-vascular endothelial growth factor
المؤلفون المشاركون
al-Sad, Muna
Shihadah, Amin
Muqbil, Jihad
al-Abbusi, Khalid
Sharif, Zuhayr
Qabalawi, Muhammad S.
المصدر
العدد
المجلد 43، العدد 1 (31 مارس/آذار 2021)، ص ص. 342-346، 5ص.
الناشر
تاريخ النشر
2021-03-31
دولة النشر
البحرين
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Purpose: Diabetic retinopathy is a major complications of diabetes mellitus and remains a leading cause for visual loss in working-age populations.
This work aims to evaluate the difference in response to anti-vascular endothelial growth factor agents based on the baseline ocular coherence tomography in patients with diabetic macular edema.
Methods: In this retrospective case-control study, the study population was evaluated and divided based on their baseline ocular coherence tomography( OCT) morphological features into cystoid, diffuse and mixed groups.
Furthermore, changes in ganglionic cell- inner plexiform layer thickness, nerve fiber layer thickness, and central macular thickness and visual acuity in patients who received intravitreal injections of anti- vascular endothelial growth factor ( anti-VEGF ) agents for diabetic macular edema were measured.
The difference in these outcome measures were studied before and after commencement of treatment for an average follow-up period of 1-year.
Results: Fifty-six eyes were included in this study.
The mean age was 60.55±10.47years (Range (25-81) years); there were 35 males (62.5%) and 21 females (37.5%).
The mean duration of follow up was 13.8 months (Range 12.0- 22.0 months) with a mean number of 4.38±2.15 injections throughout follow up.
The ocular coherence tomographic morphology of diabetic macular edema was cystoid (42.9%), diffuse (48.2%), and mixed (8.9%).
Post hoc comparisons using the Tukey HSD test showed that the mean changes in central macular thickness in the cystoid group (93.21±145.82 µm) was significantly different from the mean differences in thickness in either diffuse group (15.26±140.36 µm) or mixed group (34.4±89.71) (p=0.02).
Conclusion: Eyes with baseline cystoid diabetic macular edema treated with intravitreal injections of anti-VEGFs were associated with significantly more reduction in central macular thickness after treatment when compared to diffuse or mixed morphology.
This finding may indicate that patients who present with cystoid macular edema have a favorable response to anti- VEGFs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Sad, Muna& Shihadah, Amin& Muqbil, Jihad& Qabalawi, Muhammad S.& al-Abbusi, Khalid& Sharif, Zuhayr…[et al.]. 2021. The baseline ocular coherence tomography morphology of diabetic macular edema as a prognostic factor for response to anti-vascular endothelial growth factor. Bahrain Medical Bulletin،Vol. 43, no. 1, pp.342-346.
https://search.emarefa.net/detail/BIM-1440176
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Sad, Muna…[et al.]. The baseline ocular coherence tomography morphology of diabetic macular edema as a prognostic factor for response to anti-vascular endothelial growth factor. Bahrain Medical Bulletin Vol. 43, no. 1 (Mar. 2021), pp.342-346.
https://search.emarefa.net/detail/BIM-1440176
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Sad, Muna& Shihadah, Amin& Muqbil, Jihad& Qabalawi, Muhammad S.& al-Abbusi, Khalid& Sharif, Zuhayr…[et al.]. The baseline ocular coherence tomography morphology of diabetic macular edema as a prognostic factor for response to anti-vascular endothelial growth factor. Bahrain Medical Bulletin. 2021. Vol. 43, no. 1, pp.342-346.
https://search.emarefa.net/detail/BIM-1440176
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 345-346
رقم السجل
BIM-1440176
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر