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The cross-talk relationship between metformin and gut microbiota
المؤلف
المصدر
Sudan Journal of Medical Sciences
العدد
المجلد 15، العدد 4 (31 ديسمبر/كانون الأول 2020)، ص ص. 425-430، 6ص.
الناشر
جامعة أم درمان الإسلامية كلية الطب
تاريخ النشر
2020-12-31
دولة النشر
السودان
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background: Metformin is the first-line oral therapy for type 2 diabetes mellitus.
However, its mode of action is poorly defined.
There is an increasing awareness regarding the cross talk of gut microbiota and metformin.
The current review aimed to assess the bidirectional relationship between metformin and gut microbiota.
Methods: Electronic search was conducted in Pub Med and the first 100 articles in Google Scholar published until November 2019.
However, only randomized controlled trials on humans published in the English language were included.
The terms “gut microbiota,” “gut flora” and “metformin” were as keywords to perform the search.
Although 124 articles were retrieved, only six met the inclusion criteria of the study.
Results: Of the six full texts of randomized controlled trials included in the study, two-thirds were published in Europe, one in the USA, and one in China.
Six hundred thirty-five patients were included and the duration of the studies ranged from seven days to six months.
The studies concluded that microbiota modulates some metformin actions on plasma glucose; while metformin enhances the abundance of microbiota that positively affect insulin resistance and plasma glucose.
Conclusion: The current review showed that microbiota dysbiosis may mediate metformin antidiabetic effects.
Whereas metformin shifted the gut microbiota toward the beneficial species ameliorating insulin resistance.
The present study might provide insights into a novel therapeutic approach to treat type 2 diabetes mellitus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mirghani, Haydar Uthman. 2020. The cross-talk relationship between metformin and gut microbiota. Sudan Journal of Medical Sciences،Vol. 15, no. 4, pp.425-430.
https://search.emarefa.net/detail/BIM-1441640
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mirghani, Haydar Uthman. The cross-talk relationship between metformin and gut microbiota. Sudan Journal of Medical Sciences Vol. 15, no. 4 (2020), pp.425-430.
https://search.emarefa.net/detail/BIM-1441640
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mirghani, Haydar Uthman. The cross-talk relationship between metformin and gut microbiota. Sudan Journal of Medical Sciences. 2020. Vol. 15, no. 4, pp.425-430.
https://search.emarefa.net/detail/BIM-1441640
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 429-430
رقم السجل
BIM-1441640
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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