Relationship between cortisol, Interleukin-6 and homocysteine in Alzheimer’s disease
المؤلفون المشاركون
Mankeshwar, Ranjit
Yeram, Neelam
Dalvi, Shubhangi
Patil, Vinayak
Kale, Vinayak
Jagiasi, Kamlesh
Abichandani, Leela
المصدر
العدد
المجلد 2021، العدد 2 (31 أغسطس/آب 2021)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2021-08-31
دولة النشر
قطر
عدد الصفحات
7
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Objective: Alzheimer’s disease (AD) is characterised by progressive cognitive decline due to neurodegen- eration.
Over activation of the hypothalamic– pituitary–adrenal axis, oxidative stress and inflam- mation potentially damage the neuronal system, affecting cognition.
Aim: This study aimed to assess the relationship between serum cortisol, Interleukin-6 (IL-6) and homocysteine (Hcy) levels in AD.
Methods: Case-Control observational study consist- ing of 71 patients with AD and 70 healthy controls above 60 years of age.
Serum samples were analysed for cortisol, IL-6 and Hcy levels using chemilumines- cence immunoassay (Immulite 1000) technique.
Cognitive functions were measured using the Mini- Mental State Examination (MMSE) Score.
AD subjects were categorised based on the modified Kuppuswamy socioeconomic status scale.
Statistical evaluation was conducted using SPSS Statistics software.
Group data were analysed using a two-tailed Student’s t-test, analysis of variance (ANOVA), the Mann–Whitney U test and Pearson’s correlation test.
Results: Serum cortisol, IL-6 and Hcy levels were significantly increased ( p , 0.01) in AD (cortisol: 19.69 ^ 8.96 ug/dl; IL-6: 10.27 ^ 2.76 pg/ml; Hcy: 23.29 ^ 3.81 mmol/l), as compared with the controls (cortisol: 13.37 ^ 5.59 ug/dl; IL-6: 3.37 ^ 0.79 pg/ml; Hcy: 8.25 ^ 2.36 mmol/l).
MMSE scores in AD were negatively correlated with cortisol, IL-6 and Hcy levels.
Conclusions: Serum cortisol, IL-6 and Hcy levels are independent biomarkers for AD progression.
Hyper- cortisolaemia, hyperhomocysteinemia and inflam- mation play important roles in AD-related cognitive dysfunction and are interlinked.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yeram, Neelam& Dalvi, Shubhangi& Patil, Vinayak& Kale, Vinayak& Jagiasi, Kamlesh& Abichandani, Leela…[et al.]. 2021. Relationship between cortisol, Interleukin-6 and homocysteine in Alzheimer’s disease. Qatar Medical Journal،Vol. 2021, no. 2, pp.1-7.
https://search.emarefa.net/detail/BIM-1442294
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yeram, Neelam…[et al.]. Relationship between cortisol, Interleukin-6 and homocysteine in Alzheimer’s disease. Qatar Medical Journal No. 2 (2021), pp.1-7.
https://search.emarefa.net/detail/BIM-1442294
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yeram, Neelam& Dalvi, Shubhangi& Patil, Vinayak& Kale, Vinayak& Jagiasi, Kamlesh& Abichandani, Leela…[et al.]. Relationship between cortisol, Interleukin-6 and homocysteine in Alzheimer’s disease. Qatar Medical Journal. 2021. Vol. 2021, no. 2, pp.1-7.
https://search.emarefa.net/detail/BIM-1442294
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6-7
رقم السجل
BIM-1442294
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر