Novel quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety as potential bactericides and fungicides: Design, synthesis, characterization and 3D-QSAR analysis
المؤلفون المشاركون
Mei, Yudong
Yang, Chunlong
Hu, Haoran
Geng, Chunwen
Wang, Xiaobin
Chen, Min
Zhang, Tingting
Lu, Aimin
Zhao, Xu
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 23، العدد 8 (31 ديسمبر/كانون الأول 2019)، ص ص. 1144-1156، 13ص.
الناشر
تاريخ النشر
2019-12-31
دولة النشر
السعودية
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
A series of quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety were designed, synthesized and evaluated for their biological activities against phytopathogenic microorganisms.
Antimicrobial bioassays in vitro indicated that most of the target compounds exhibited more significant antibacterial activities against Xanthomonas oryzae pv.
oryzae (Xoo) than the agricultural bactericide thiadiazol-copper.
A comparative molecular similarity index analysis (CoMSIA) model with cross-validated q2 and non-cross-validated r2 values of 0.561 and 0.882 was generated to investigate the structure-activity relationships of title compounds against Xoo.
Title compound 6w, which was rationally designed under the guidance of obtained CoMSIA model, exhibited the excellent anti-Xoo effect in vitro with an EC50 value of 29.10 lg/mL, which is approximately 3-folds more effective than thiadiazole-copper (113.93 lg/mL).
In addition, compound 6i demonstrated the impressive antifungal effects against Rhizoctonia solani (Rs) and Fusarium gramine arum (Fg) in vitro, with the corresponding EC50 values of 11.01 lg/mL and 36.00 lg/mL, which is obviously better than the agricultural fungicide hymexazol (76.74 lg/mL and 56.19 lg/mL, respectively).
The above researches indicate that quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety could be further studied as template molecules of novel agricultural microbicides.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiaobin& Hu, Haoran& Zhao, Xu& Chen, Min& Zhang, Tingting& Geng, Chunwen…[et al.]. 2019. Novel quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety as potential bactericides and fungicides: Design, synthesis, characterization and 3D-QSAR analysis. Journal of Saudi Chemical Society،Vol. 23, no. 8, pp.1144-1156.
https://search.emarefa.net/detail/BIM-1443239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiaobin…[et al.]. Novel quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety as potential bactericides and fungicides: Design, synthesis, characterization and 3D-QSAR analysis. Journal of Saudi Chemical Society Vol. 23, no. 8 (Dec. 2019), pp.1144-1156.
https://search.emarefa.net/detail/BIM-1443239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiaobin& Hu, Haoran& Zhao, Xu& Chen, Min& Zhang, Tingting& Geng, Chunwen…[et al.]. Novel quinazolin-4(3H)-one derivatives containing a 1,3,4-oxadiazole thioether moiety as potential bactericides and fungicides: Design, synthesis, characterization and 3D-QSAR analysis. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 8, pp.1144-1156.
https://search.emarefa.net/detail/BIM-1443239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1155-1156
رقم السجل
BIM-1443239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر