Synthesis, physico-chemical studies and biological evaluation of new metal complexes with some pyrazolone derivatives
المؤلفون المشاركون
Bondock, Samir
al-Shahri, Asma Abd Allah Zafir
Ahmad M. Ramadan
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 23، العدد 8 (31 ديسمبر/كانون الأول 2019)، ص ص. 1192-1205، 14ص.
الناشر
تاريخ النشر
2019-12-31
دولة النشر
السعودية
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
A series of N-substituted-4-thiocarbamoyl-5-pyrazolone derivatives (HL1 -HL4 ) is presented as chelating agents for complexation with Fe(III), Ni(II) and Cu(II) metal ions.
The synthesized pyrazolone ligands and their newly metal complexes are characterized by different spectral and analytical methods such as UV–Vis, IR, 1 H NMR, 13C NMR, ESR, MS, magnetic measurement, and TGA.
The spectral data reveal that ligands coordinated to metal ions in a bidentate pat tern via O & N atoms of the OH group at C(5) and thiocarbamoyl (–CSNHR) at C(4) of the pyrazolone ring.
Also, the analytical data suggest the stoichiometries 2:3 (M: L) for both Cu (II) & Ni(II) complexes and 1:3 for Fe(III) complexes.
Besides, the normal magnetic moments values for Fe(III) complexes confirm high spin octahedral structure while the diamagnetic nature of all Ni(II) complexes is consistent with square planar geometry.
However, the subnormal magnetic values for Cu(II) complexes suggest the proposal of their binuclear structures.
The ESR spectra of the Cu (II) complexes support the distorted square planar geometry with a considerably strong intradimeric spin-exchange interaction.
Moreover, the anticancer, antibacterial and antifungal activities are screened.
Among the synthesized compounds, HL4 ligand exhibits a significant broad spectrum of action against Gram-positive (S.
aureus), Gram-negative bacteria (P.
vulgaris), and antifungal potency against A.
fumigatus & C.
albicans in comparison with gentamicin and ketoconazole drug.
Such potency of HL4 could be related to the insertion of the pchloro in the phenyl group attached the pharmacophoric thiocarbamoyl group at C(4).
Furthermore, IC50 values of two Cu(II) complexes derived from HL2 and HL3 display nearly twofold or threefold more cytotoxicity impact against three cell lines (MCF-7, HCT116 and HepG-2) compared with cis-platin as positive control.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmad M. Ramadan& al-Shahri, Asma Abd Allah Zafir& Bondock, Samir. 2019. Synthesis, physico-chemical studies and biological evaluation of new metal complexes with some pyrazolone derivatives. Journal of Saudi Chemical Society،Vol. 23, no. 8, pp.1192-1205.
https://search.emarefa.net/detail/BIM-1443248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Shahri, Asma Abd Allah Zafir…[et al.]. Synthesis, physico-chemical studies and biological evaluation of new metal complexes with some pyrazolone derivatives. Journal of Saudi Chemical Society Vol. 23, no. 8 (Dec. 2019), pp.1192-1205.
https://search.emarefa.net/detail/BIM-1443248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmad M. Ramadan& al-Shahri, Asma Abd Allah Zafir& Bondock, Samir. Synthesis, physico-chemical studies and biological evaluation of new metal complexes with some pyrazolone derivatives. Journal of Saudi Chemical Society. 2019. Vol. 23, no. 8, pp.1192-1205.
https://search.emarefa.net/detail/BIM-1443248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1203-1205
رقم السجل
BIM-1443248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر