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Beneficial role of Echinacea against lead acetate-induced brain toxicity through reducing inflammation, oxidative stress and apoptosis in rats
المؤلفون المشاركون
Abbas, Manal Munir
Mahmud, Amal H.
Abd al-Munim, Hanan A.
المصدر
Arab Journal of Nuclear Sciences and Applications
العدد
المجلد 56، العدد 1 (31 يناير/كانون الثاني 2023)، ص ص. 55-68، 14ص.
الناشر
الجمعية المصرية للعلوم النووية و تطبيقاتها
تاريخ النشر
2023-01-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : lead is widely distributed in the environment and has been associated with a variety of negative health impacts.
the present study investigated the use of Echinacea with lead acetate in decreasing or preventing the serious side effects of lead on the brains of male rats.
methods : twenty-four rats were distributed into four groups randomly.
group 1 : rats orally administered 1Ml of distilled water followed by an intraperitoneal (I.P) injection of 1Ml of physiological saline (control group).
group 2 : rats I.
p injected with lead acetate (50 mg / kg b.
w / day, 3 days a week for 4 weeks).
group 3 : rats orally administered Echinacea (150 mg / kg b.
w.
/ day for 4 weeks).
group 4 : rats administrated with echinacea plus lead acetate with the same doses of G2 and G3.
Results : lead exposure resulted in a significant elevation in nitric oxide (NO) production and malondialdehyde (MDA), along with a decline in reduced glutathione (GSH) and enzyme activities of superoxide dismutase (SOD) and catalase (CAT) in the rats' brain.
these results were linked with significant increases in aminotransferase enzymes, lactate dehydrogenase (LDH), alkaline phosphatase (ALP) in brain tissues and serum thyroid stimulating hormone (TSH) levels.
abnormal histopathological changes and increased caspase-3 immunopositivity were also observed in comparison to control.
the co-treatment with Echinacea in lead-exposed rats improved all of these changes.
conclusions : this study pointed out that Echinacea could be used as an alternative treatment to counteract the negative effects of lead acetate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abd al-Munim, Hanan A.& Mahmud, Amal H.& Abbas, Manal Munir. 2023. Beneficial role of Echinacea against lead acetate-induced brain toxicity through reducing inflammation, oxidative stress and apoptosis in rats. Arab Journal of Nuclear Sciences and Applications،Vol. 56, no. 1, pp.55-68.
https://search.emarefa.net/detail/BIM-1443600
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abd al-Munim, Hanan A.…[et al.]. Beneficial role of Echinacea against lead acetate-induced brain toxicity through reducing inflammation, oxidative stress and apoptosis in rats. Arab Journal of Nuclear Sciences and Applications Vol. 56, no. 1 (Jan. 2023), pp.55-68.
https://search.emarefa.net/detail/BIM-1443600
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abd al-Munim, Hanan A.& Mahmud, Amal H.& Abbas, Manal Munir. Beneficial role of Echinacea against lead acetate-induced brain toxicity through reducing inflammation, oxidative stress and apoptosis in rats. Arab Journal of Nuclear Sciences and Applications. 2023. Vol. 56, no. 1, pp.55-68.
https://search.emarefa.net/detail/BIM-1443600
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 65-68
رقم السجل
BIM-1443600
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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