The effect of Olive Oil on hematotoxicity induced by ibuprofen in male Rabbits

الملخص EN

Ibuprofen is known as a nonsteroidal anti-inflammatory drugs (NSAIDs), described as analgesic, antipyretic and anti-inflammatory agent.

Ibuprofen had been notified to be linked with some adverse effects.

This present study was performed to find out the toxic effects of ibuprofen on blood cell components of male rabbits, as well as to evaluate the effective role of olive oil in reducing its toxicity.

A total of eighteen male rabbits weighing between (900-1000 g) selected randomly from the local market.

The study sample was categorized into three groups: six male rabbits control group orally administered with distilled water once per day for 30 days, six male rabbits group orally administered with (40 mg/kg) ibuprofen once per day for 30 days and six male rabbits group orally administered with (40 mg/kg) ibuprofen and 2 ml/kg of olive oil once per day for 30 days.

At the end of experiment, all experimental animals were sacrificed and blood sample was collected.

Red blood cells mass and indices, white blood cells count and differential, as well as platelets count were estimated using a hematological autoanalyzer instrument.

The results showed 40 mg of ibuprofen caused a significant decrease (P˂ 0.001) in the mass and indices of red blood cells and platelets counts.

Also, a significant increase showed in total of white blood cells and disturbances of differential in ibuprofen group compared with control group.

The use of olive oil had a positive effect against the hematotoxicity of ibuprofen, the results recorded improvement in the level of blood components in ibuprofen and olive oil group compared with ibuprofen group.

In conclusion, regular intake of olive oil syrup may be useful in improving blood components and may reduce the hematotoxicity of ibuprofen agent.

Further studies at molecular level are needed to know the exact mechanism of ibuprofen hematotoxicity.