![](/images/graphics-bg.png)
Short stature, body disproportion, and endocrine disorders in thalassemia major
العناوين الأخرى
قصر القامة و عدم تناسق الجسم و إضطرابات الغدد الصم لدى المرضى المصابين بالثلاسيميا الكبرى
المصدر
Journal of the Arab Board of Health Specializations
العدد
المجلد 5، العدد 3 (31 أغسطس/آب 2003)، ص ص. 30-34، 5ص.
الناشر
المجلس العربي للاختصاصات الصحية
تاريخ النشر
2003-08-31
دولة النشر
سوريا
عدد الصفحات
5
التخصصات الرئيسية
الملخص AR
Objectives: Short stature and endocrine disorders are common complications of fi thalassemia major (TM).
The aim of this study was to determine the prevalence and causes of short stature, body disproportion, delayed puberty, and skeletal changes among thalassemia patients in our area.
Methods: A prospective study was done on 314 patients with TM, randomly chosen at the Thalassemic Treatment Center of Al Yarmook Teaching Hospital during the period from January 2, 2001 to April 30, 2001.
Patients ranged from 2-20 years of age and were divided into 5 groups.
The male to female ratio was 1.2:1.
The study included measurements of standing height, ratio of upper body to lower segment, puberty staging according to Tanner staging.
Estimation of the hormones for which assays were available including growth hormone, T4, TSH, LH, and FSH, were performed.
The liver enzymes AST and ALI, and serum calcium were measured.
Radiographs of the head, long bones, vertebrae, and wrist joints were done.
The abnormalities noted were correlated with the duration of the DFX chelation and serum ferritin levels.
Results: The study revealed that 28% of the patients exhibited short stature, predominantly in the age group 15- 20 years, and 25% of the patients had short trunk but normal stature predominantly in the age group of 10-14.
There was a significant relation to the duration of DFX chelation, p=0.0004.
Delayed puberty was present in 33/63 patients (52.4%); 19 were females (57.5%) and 14 were males (42.5%).
Endocrine disorders were present in 25.9%.
Hypo gonadotropic hypogonadism and hypocalcemia were present in 8.4% and 12% of the patients respectively.
There was a significant relation to the duration of the disease, p=0.00003 and 0.0004 respectively.
Skeletal changes including platyspondylosis, maxillary overgrowth, hair-on-end appearance, rectangular metacarpals and metatarsals, and osteoporosis were found in 38.6% of the patients in the age group of 10-14 years and were significantly related to the duration of DFX chelation, p=0.0001.
Conclusion: Short stature, short trunk, skeletal changes and delayed puberty are significant problems in our thalassemic patients.
The role of siderosis and DFX toxicity need further elucidation.
الملخص EN
Objectives: Short stature and endocrine disorders are common complications of fi thalassemia major (TM).
The aim of this study was to determine the prevalence and causes of short stature, body disproportion, delayed puberty, and skeletal changes among thalassemia patients in our area.
Methods: A prospective study was done on 314 patients with TM, randomly chosen at the Thalassemic Treatment Center of Al Yarmook Teaching Hospital during the period from January 2, 2001 to April 30, 2001.
Patients ranged from 2-20 years of age and were divided into 5 groups.
The male to female ratio was 1.2:1.
The study included measurements of standing height, ratio of upper body to lower segment, puberty staging according to Tanner staging.
Estimation of the hormones for which assays were available including growth hormone, T4, TSH, LH, and FSH, were performed.
The liver enzymes AST and ALI, and serum calcium were measured.
Radiographs of the head, long bones, vertebrae, and wrist joints were done.
The abnormalities noted were correlated with the duration of the DFX chelation and serum ferritin levels.
Results: The study revealed that 28% of the patients exhibited short stature, predominantly in the age group 15- 20 years, and 25% of the patients had short trunk but normal stature predominantly in the age group of 10-14.
There was a significant relation to the duration of DFX chelation, p=0.0004.
Delayed puberty was present in 33/63 patients (52.4%); 19 were females (57.5%) and 14 were males (42.5%).
Endocrine disorders were present in 25.9%.
Hypo gonadotropic hypogonadism and hypocalcemia were present in 8.4% and 12% of the patients respectively.
There was a significant relation to the duration of the disease, p=0.00003 and 0.0004 respectively.
Skeletal changes including platyspondylosis, maxillary overgrowth, hair-on-end appearance, rectangular metacarpals and metatarsals, and osteoporosis were found in 38.6% of the patients in the age group of 10-14 years and were significantly related to the duration of DFX chelation, p=0.0001.
Conclusion: Short stature, short trunk, skeletal changes and delayed puberty are significant problems in our thalassemic patients.
The role of siderosis and DFX toxicity need further elucidation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Said, Najla I. M.& Mansi, A. M.& al-Naqib, Wafa. 2003. Short stature, body disproportion, and endocrine disorders in thalassemia major. Journal of the Arab Board of Health Specializations،Vol. 5, no. 3, pp.30-34.
https://search.emarefa.net/detail/BIM-146320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Said, Najla I. M.…[et al.]. Short stature, body disproportion, and endocrine disorders in thalassemia major. Journal of the Arab Board of Health Specializations Vol. 5, no. 3(August 2003), pp.30-34.
https://search.emarefa.net/detail/BIM-146320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Said, Najla I. M.& Mansi, A. M.& al-Naqib, Wafa. Short stature, body disproportion, and endocrine disorders in thalassemia major. Journal of the Arab Board of Health Specializations. 2003. Vol. 5, no. 3, pp.30-34.
https://search.emarefa.net/detail/BIM-146320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 34
رقم السجل
BIM-146320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)