Acrylamide toxicity and therapeutic effect of vitamin C on albino rats immunological parameters

الملخص EN

Acrylamide (ACR) is a widespread industrial chemical with recognized adverse effects not only to humans but to other organisms in the environment as well, Acrylamide forms during the heating of starchy foods at high temperature, and is regarded as a potential genotoxic carcinogen.

However, with the worldwide concern about the carcinogenicity of ACR, how to reduce the toxicity of ACR has become a hot research topic.

In this study, albino rats were divided into three groups; control rats, rats treated with acrylamide and rats treated with ACR and Vit C.

Results revealed that significant changes were observed in immunological parameters where there was no significant decrease (P > 0.05) in level of TNF-α in rats treated with ACR,there significant increase in the mean level of- TNF-α in rats treated with ACR, treated with Vit C, and there was significant decrease (P < 0.0001) in level of IL-17in rats treated with acrylamide there significant decrease (P < 0.05) in the mean level of IL-17 in rats treated with ACR, treated with Vit C with compared with control group , Therefore, our investigation revealed that Vit C appeared to be a promising agent for protection against ACR -induced toxicity.

This study aims to clarify the therapeutic role of Vit C to avoid exposure to ACR, which can come from several sources, and the role of Vit C in influencing some indicators of immunity in the body.