A role of therapy that targets immune checkpoint proteins for the treatment of melanoma brain metastasis, liver, breast, pancreatic cancer and pancreatic adenocarcinoma
المؤلفون المشاركون
Muhammad, Sama al-Sayyid
Yusuf, Basmah Amal
Ghunnay, Dua Ala
Ahmad, Iman Faris
Muhammad, Isra Gharib
Abduh, Mayy Ashraf
Muhammad, Mayy Isam
Hassan, Rana Gharib
Muhammad, Rim Muhammad
Abd al-Azim, Rufaydah Ahmad
Suwaylim, Sarah Adil
Salman, Sarah Awdah
al-Aiyq, Sarah Muhammad
Taha, Tuqa Taha
Muawwad, Zaynab Khalid
المصدر
al-Kindy College Medical Journal
العدد
المجلد 18، العدد 3 (31 ديسمبر/كانون الأول 2022)، ص ص. 173-180، 8ص.
الناشر
تاريخ النشر
2022-12-31
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Checkpoint inhibitors are a type of immune therapy used to treat different types of cancers.
These drugs block different checkpoint proteins, for example, CTLA-4, PD-1, and PD-L1 inhibitors.
They block proteins that stop the immune system from attacking the cancer cells.
Checkpoints are also described as a type of monoclonal antibody that antagonizes binding between B7 to CTLA-4 and PD-L1 to PD-1.
Immune checkpoint inhibitors are used to treat BARCA mutated triple-negative breast cancer (TNBCS) in patients who do not respond to chemotherapy, and also in the treatment of highly mutated and solid tumors such as brain tumors, liver, and pancreatic cancers.
Immune checkpoint inhibitors exhibit an effect on solid tumors by suppressing CTLA-4, PD-1, and PDL-1.
Anti-PD-1 is less toxic than anti-CTLA-4.
For melanoma Brain metastasis immune checkpoint therapy is more effective and Combination therapy has great efficacy and less toxicity which improves overall survival rather than individual therapy liver cancer as hepatocellular carcinoma and cholangiocarcinoma used treatment with Genetics based therapy while using alternative immune checkpoint ligands, co-inhibitory (eg.
LAG-3) or decreased t-cell infiltration causing therapy failure.
Clinical studies for pancreatic cancer have not been completed yet and treating PDA needs more research as immune checkpoint inhibitors is a new treatment against PDA.
A new potent class of nivolumab, pembrolizumab, and ipilimumab have been FDA approved.
For mutated tumors, Combination therapy between checkpoint inhibitors and chemotherapy has great efficacy and improves the city of life and overall survival, rather than individual therapy when using radiation or chemotherapy alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Sama al-Sayyid& Yusuf, Basmah Amal& Ghunnay, Dua Ala& Ahmad, Iman Faris& Muhammad, Isra Gharib& Abduh, Mayy Ashraf…[et al.]. 2022. A role of therapy that targets immune checkpoint proteins for the treatment of melanoma brain metastasis, liver, breast, pancreatic cancer and pancreatic adenocarcinoma. al-Kindy College Medical Journal،Vol. 18, no. 3, pp.173-180.
https://search.emarefa.net/detail/BIM-1492882
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Sama al-Sayyid…[et al.]. A role of therapy that targets immune checkpoint proteins for the treatment of melanoma brain metastasis, liver, breast, pancreatic cancer and pancreatic adenocarcinoma. al-Kindy College Medical Journal Vol. 18, no. 3 (Dec. 2022), pp.173-180.
https://search.emarefa.net/detail/BIM-1492882
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Sama al-Sayyid& Yusuf, Basmah Amal& Ghunnay, Dua Ala& Ahmad, Iman Faris& Muhammad, Isra Gharib& Abduh, Mayy Ashraf…[et al.]. A role of therapy that targets immune checkpoint proteins for the treatment of melanoma brain metastasis, liver, breast, pancreatic cancer and pancreatic adenocarcinoma. al-Kindy College Medical Journal. 2022. Vol. 18, no. 3, pp.173-180.
https://search.emarefa.net/detail/BIM-1492882
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 177-180
رقم السجل
BIM-1492882
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر