Action of estrogen in breast cancer : a review study
المؤلفون المشاركون
Ibrahim, Suud Latif
Berkson, Rachel
المصدر
Kufa Journal for Nursing Sciences
العدد
المجلد 12، العدد 2 (31 ديسمبر/كانون الأول 2022)، ص ص. 10-20، 11ص.
الناشر
تاريخ النشر
2022-12-31
دولة النشر
العراق
عدد الصفحات
11
التخصصات الرئيسية
العلوم الطبية والصيدلة والعلوم الصحية
الملخص EN
Estrogen hormone is one of the steroid hormones has a critical role in breast cancer etiology.
It has been implicated in proliferation and differentiation of cells through its action promoting binding of its receptor to DNA, changing transcriptional expression of target genes.
In addition to the classical DNA binding mechanism, estrogen can also regulate gene expression through a no genomic mechanism associated with uf activation a variety of signal transduction pathways (e.g.
PI3K/AKT, ERK/MAPK, PLC/PKCS, p38/MAPK).
Dysregulation of the balance between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, would result in apoptosis inhibition and tumor genesis (Chimento et al., 2022).
Also, poor responses towards hormonal therapy, radiotherapy, and chemotherapy and treatment resistance are likely caused by dysregulation of apoptosis.
Importantly, E2 has been shown to prevent apoptosis, first through its action in activation of anti-apoptotic proteins like Bcl-xl and Bcl-2 in breast cells like MCF-7, T47D and ZR-75-1 or due to its metabolites independently of ER.
Estrogen metabolism includes several very important pathways that can possibly induce de novo DNA mutation.
These pathways include : 2, &4-hydroxylation, 16 a hydroxylation and 4 hydroxyestradiol-quinone-adenine/guanine adduct depurination, which subsequently participate in DNA damage that can lead to breast cancer.
Endocrine resistance is considered one of the most permanent problems that can reduce the benefits of breast cancer treatment.
Alteration of microRNAs expression, polymorphisms occurring in tamoxifen metabolism, and using redundant alternative signaling pathways, resulting in poor treatment responses of breast cancer patients and induction of endocrine resistance.
Thus, most proposed therapeutic strategies will be based on a combination of drugs targeting various pathways alongside endocrine therapy that may improve the outcomes of endocrine responses in resistant breast cancer cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Suud Latif& Berkson, Rachel. 2022. Action of estrogen in breast cancer : a review study. Kufa Journal for Nursing Sciences،Vol. 12, no. 2, pp.10-20.
https://search.emarefa.net/detail/BIM-1492938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Suud Latif& Berkson, Rachel. Action of estrogen in breast cancer : a review study. Kufa Journal for Nursing Sciences Vol. 12, no. 2 (Jul. / Dec. 2022), pp.10-20.
https://search.emarefa.net/detail/BIM-1492938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Suud Latif& Berkson, Rachel. Action of estrogen in breast cancer : a review study. Kufa Journal for Nursing Sciences. 2022. Vol. 12, no. 2, pp.10-20.
https://search.emarefa.net/detail/BIM-1492938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 18-20
رقم السجل
BIM-1492938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر