Evaluation of the antioxidant activity of zingiber officinale alcoholic extract and vitamin e on liver damage induced by paracetamol drug in males of new Zealand rabbits

الملخص EN

The aim of study is to reduce hepatic damage from paracetamol will be funded using alcohol extract for ginger and vitamin E as antioxidants in male New Zealand rabbits.

Paracetamol (acetaminophen) is a widely used over-the-counter analgesic and antipyretic drug which is known to cause liver injuries in both humans and experimental animals when administered in overdose.

The current study was conducted at the animal house of the College of Veterinary Medicine, Tikrit University to detect certain side effects developed with the use of the drug paracetamol, some physiological values resulting from liver damage through the use of 40 male New Zealand rabbits aged 5-7 months, randomly divided into four equal groups, including : The control group were given the normal physiological solution and the second group were given the paracetamol drug was given orally 400 mg/kg per rabbit while the third group was given vitamin e 50 mg/kg body weight as well as 400 mg/kg of the paracetamol drug was given orally.

The fourth group was dosed with ginger alcoholic extract of 150 mg/kg body weight, which was given 400 mg/kg of the paracetamol drug was given orally.

The study's findings demonstrated a significant decrease in the levels of catalase (CAT), super oxidase dismutase (SOD) and glutathione (GSH) in the treatment with a paracetamol drug compared to the control group, as well as a significant increase in the levels of liver enzymes and malondialdehyde.

The study's results also found a significant decline in the levels of liver enzymes and malondialdehyde while revealing a significant increase in the levels of CAT, SOD and GSH in 3rd and 4th group compared to 2nd group.

From the aforementioned findings, it can be concluded that vitamin e and ginger alcohol extract both reduce the unfavorable and harmful effects in some physiological parameters coming from liver damage caused by Paracetamol drug usage.