OxLDL is a possible marker for increased risk of acute coronary syndromes in Syrian patients

الملخص EN

Objective: The aim of this study was to evaluate the usefulness of circulating oxidized low-density lipoprotein (OxLDL) as a risk marker of coronary artery disease (CAD) expressed in acute coronary syndromes (ACS) in comparison to low-density lipoprotein (LDL).

Methods: A total of 78 subjects were included: 60 patients with angiographically proven acute coronary syndromes divided into acute myocardial infarction group (AMI, n=30) and unstable angina group (UA, n=30) and 18 subjects without clinical evidence of coronary artery disease served as controls.

OxLDL levels were measured by sandwich enzyme-linked immunosorbent assay (ELISA).

LDL levels were measured using enzymatic method.

Results: Plasma levels of OxLDL were significantly higher in each disease group than in control (p<0.001).

The highest OxLDL levels were associated with the presence of hypertension and/or diabetes.

OxLDL levels were correlated strongly with LDL levels in controls but weakly in ACS patients.

The sensitivity and specificity for diagnosing ACS were 93% and 89% respectively for OxLDL versus 77% and 72% for LDL.

Conclusion: Circulating OxLDL is a better biomarker than LDL for discriminating between patients with ACS and healthy subjects.

High levels of OxLDL could be a promising risk marker for coronary artery disease (CAD).