Flavonoids, pharmacological and antitumor activities of convolvulus althaeoides l. Extracts

الملخص EN

Eight flavonoid compounds were isolated from the alcoholic extract of Convolvulus althaeoides L.

They are Kaempferol, kaempferol-3-rhamnoside 7- glycoside, quercetin, ruin (quercetin-3-rhamnoglucoside), kaempferol-3- rhamnoside, quercetin-3-glycoside, kaempferol-3, 7-di-rhamnoside and kaempferol-3-rhamnoside-7-rhamnoxyloside.

Their structures were elucidated by spectroscopic methods including Ultraviolet (UV), Electron impact mass (EI mass), 2 Dimensional Nuclear Magnetic Resonance for Hydrogen Proton and Carbon thirteen 1H and 13C 2D NMR), DEPT, Hetro nuclear Multiplier Bonding Correlation (HMBC) and Hetro nuclear Multiplier Quantum Correlation (HMQC) experiments.

The butane extract of the plant have high cytotoxic activity against Ehrlich tumor cell line, while other extracts and some isolated compounds showed a significant activity.

Pharmacological screening was also performed which showed that repeated oral administration of ruin, aqueous and butane extracts reduced the severity of gastric damage while ruin and aqueous extract in a dose of 300 mg / kg b.

wt, increased the time required for blood coagulation.

The volume of urine was significantly increased in rats administered with ruin, also the aqueous and butane extracts produced 20 % protection against writhing after 3-4 h of their oral administration.