Body weight effect on the outcome of assisted reproductive treatment

الملخص EN

Background : changes of body mass index have an adverse effect on female fecundity but there is controversy about its effect on outcomes of assisted reproductive treatment.

Objective: to examine the relationship between BMI and 1VF / ICS1 outcome in our unit.

Design and setting: a retrospective analysis of prospectively collected data from the fertility centre in a tertiary hospital.

Patients and Methods: 1780 consecutive IVF / 1CS1 treatment cycles performed between the financial year 2000 and 2003.

Patients were divided into four groups according to their BMI: Group A (BMI <19 kg / ml); Group B (BMI between 19 and 24.9 kg / m2); Group C (BMI 25 to 29.9 Icg / m2) and Group D (BMI> 30 kg / in2).

Standard pituitary down-regulation and ovarian stimulation with FSH and HCG were done for buth IVF / 1CSI patients with progesterone luteal phase support.

The mean number of mature follicles, acolytes collected, fertilization rate, and the pregnancy rates were analysed between groups.

Results : a total of 1780 cycles in the form of IVF (1156 cycles, 65%) and 1CSI (584 cycles, 32.8%) with 40 cycles had been cancelled (2.2%).

The majority of cycles were under group B (BMI 19 - 24.9) and group C (BMI 25 - 29.9) which represent 80% of all treatment cycles.

Linear association was observed between higher BMI and longer stimulation and requirement for increased total doses of FSII (P < 0.00 1).

The clinical pregnancy rate was significantly reduced with increased BMI (I3 < 0.02).

Conclusion : obesity is associated with lower clinical pregnancy rate and the need for higher and longer period of FSH stimulation but underweight was not related to an impaired outcome.