Phytochemical and biological studies of sisymbrium irio l. Growing in egypt

الملخص EN

Eight flavonoid compounds were isolated for the first time from the aerial parts of Sisymbrium irio L.

by the chromatographic methods and identified as ; Apigenin, apigenin-7-galactoside, apigenin-7-O-β-Dglucoside, luteolin-7-O-glucoside, apigenin-7-di-glucoside, apigenin-7-O- (6``acetyl) glucoside, apigenin.

7-O-gluco (6``-1```) rhamnoside and apigenin-7-O-gluco (6``-1```) rhamnoside-5-methoxide.

Their identities were established by m.

p., UV, 600MHz 1H and 13C NMR.

The plant under study seems to be safe due to high value of median lethal dose (over 4000 mg / kg b.

wt.) showed that.

Biological activities were carried out for all extracts (chloroform, ethyl acetate and butanol).

Only chloroform extract showed moderate anti-inflammatory activity.

Both chloroform and butanol extracts had significant diuretic activity.

The antidiabetic effect was induced by ethyl acetate and butanol extracts.

On the other hand no effect on Ehrlich ascities carcinoma (E.

A.

C.) was noticed.