Sister chromatid exchange in peripheral blood lymphocytes as a possible breast cancer risk biomarker : a study of Iranian patients with breast cancer
المؤلفون المشاركون
Nejad, Kyumars Safi
Mahdieh, Najah
Mahdipour, Parvin
Yadegar, Layla
Atri, Murtada
Javadi, Gholamreza
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 10، العدد 1 (31 مايو/أيار 2009)، ص ص. 55-61، 7ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2009-05-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Introduction: Sister chromatid exchanges (SCEs) can be induced by various genotoxic treatments, suggesting that SCEs refl ect a DNA repair process and it may be a good index for assessment of genomic instability.
However, the occurrence of genetic instability and in particular, of spontaneous SCEs has been strongly linked to cancer.
Several chromosomal regions and many genes have been implicated in breast cancer.
Materials and Methods: Blood samples were obtained from 31 Iranian breast cancer patients and 11 healthy women.
SCE was measured in peripheral blood lymphocytes by adding to Ham’sF10 medium in presence of PHA, BrdU (5-bromo-deoxy Uridine) fl uorochrome Hoechst 33258, exposure to UV light and Giemsa staining.
Then, SCE frequencies of patient and control groups were compared by the Mann-Withney U-test.
Results: Signifi cantly difference was observed between two groups (p<0.001).
Conclusion: This study indicates that SCE can be used as a risk biomarker for breast cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nejad, Kyumars Safi& Mahdieh, Najah& Mahdipour, Parvin& Yadegar, Layla& Atri, Murtada& Javadi, Gholamreza. 2009. Sister chromatid exchange in peripheral blood lymphocytes as a possible breast cancer risk biomarker : a study of Iranian patients with breast cancer. The Egyptian Journal of Medical Human Genetics،Vol. 10, no. 1, pp.55-61.
https://search.emarefa.net/detail/BIM-203851
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nejad, Kyumars Safi…[et al.]. Sister chromatid exchange in peripheral blood lymphocytes as a possible breast cancer risk biomarker : a study of Iranian patients with breast cancer. The Egyptian Journal of Medical Human Genetics Vol. 10, no. 1 (May. 2009), pp.55-61.
https://search.emarefa.net/detail/BIM-203851
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nejad, Kyumars Safi& Mahdieh, Najah& Mahdipour, Parvin& Yadegar, Layla& Atri, Murtada& Javadi, Gholamreza. Sister chromatid exchange in peripheral blood lymphocytes as a possible breast cancer risk biomarker : a study of Iranian patients with breast cancer. The Egyptian Journal of Medical Human Genetics. 2009. Vol. 10, no. 1, pp.55-61.
https://search.emarefa.net/detail/BIM-203851
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 59-61
رقم السجل
BIM-203851
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر