EEG changes and neuroimaging abnormalities in relevance to severity of autism
المؤلفون المشاركون
Kotoury, Ahmad I.
al-Kamah, Ghadah Y.
Ibrahim, Samira I.
Ashaat, Engy A.
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 10، العدد 1 (31 مايو/أيار 2009)، ص ص. 63-71، 9ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2009-05-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Autism is currently viewed as a genetically determined neurodevelopmental disorder although its defi nite underlying etiology remains to be established.
Aim of the Study: Our purpose was to assess autism related morphological neuroimaging changes of the brain and EEG abnormalities in correlation to the degree of disease severity.
Patients and Methods: Seventeen cases with classic autism, 13 males and 4 females were included in the study.
Severity of the disease was assessed both clinically and by Childhood Autism Rating Scale (CARS).
MRI changes and EEG abnormalities were detected in seven patients, mostly severely and moderately affected.
Results: Hypoplasia of cerebellar vermian lobules is the most replicated MRI abnormality in our patients (18%).
Periventricular white matter dysmyelination is detected in 12% of studied cases.
29% of the cases have EEG abnormalities.
Head circumference above 97th centiles is detected in 18% of cases.
The increased head circumference, when in combination with EEG abnormalities, positively correlates with the degree of disease severity.
Conclusion: Although, no defi nite correlation could be established between the studied parameters and disease severity, most patients in the present study who exhibited MRI abnormality, EEG changes and/or increased head circumference (H.C) manifested severe form of autism.
The absence of correlation may be attributed to lack of statistical power, resulting from small sample size.
However, the correlation was not solidly excluded therefore, the recommendation of further neuroradiological evaluation as well as the implementation of newer techniques, might help future elucidating the etiology of autism.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kotoury, Ahmad I.& al-Kamah, Ghadah Y.& Ibrahim, Samira I.& Ashaat, Engy A.. 2009. EEG changes and neuroimaging abnormalities in relevance to severity of autism. The Egyptian Journal of Medical Human Genetics،Vol. 10, no. 1, pp.63-71.
https://search.emarefa.net/detail/BIM-203860
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kotoury, Ahmad I.…[et al.]. EEG changes and neuroimaging abnormalities in relevance to severity of autism. The Egyptian Journal of Medical Human Genetics Vol. 10, no. 1 (May. 2009), pp.63-71.
https://search.emarefa.net/detail/BIM-203860
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kotoury, Ahmad I.& al-Kamah, Ghadah Y.& Ibrahim, Samira I.& Ashaat, Engy A.. EEG changes and neuroimaging abnormalities in relevance to severity of autism. The Egyptian Journal of Medical Human Genetics. 2009. Vol. 10, no. 1, pp.63-71.
https://search.emarefa.net/detail/BIM-203860
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 69-71
رقم السجل
BIM-203860
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر